阿奇霉素、克拉霉素及其他抗生素对肺炎衣原体的体外活性
In vitro activities of azithromycin, clarithromycin, and other antibiotics against Chlamydia pneumoniae.
作者信息
Kuo C C, Jackson L A, Lee A, Grayston J T
机构信息
Department of Pathobiology, University of Washington, Seattle 98195, USA.
出版信息
Antimicrob Agents Chemother. 1996 Nov;40(11):2669-70. doi: 10.1128/AAC.40.11.2669.
Abstract
The in vitro susceptibilities of Chlamydia pneumoniae isolates to macrolide, tetracycline, and quinolone antibiotics were determined. Tetracycline, clarithromycin, and erythromycin had the lowest MICs in the first cell culture passage. Azithromycin required the lowest concentration for complete inhibition of inclusion formation on the second pass into antibiotic-free medium, likely reflecting its high intracellular concentrations.
摘要
测定了肺炎衣原体分离株对大环内酯类、四环素类和喹诺酮类抗生素的体外敏感性。在第一次细胞培养传代中，四环素、克拉霉素和红霉素的最低抑菌浓度最低。阿奇霉素在第二次传代至无抗生素培养基时，完全抑制包涵体形成所需的浓度最低，这可能反映了其在细胞内的高浓度。
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