Ellis B A, Regnery R L, Beati L, Bacellar F, Rood M, Glass G G, Marston E, Ksiazek T G, Jones D, Childs J E
Viral and Rickettsial Zoonoses Branch, Centers for Disease Control, Atlanta, GA 30333, USA.
J Infect Dis. 1999 Jul;180(1):220-4. doi: 10.1086/314824.
Bartonella species were isolated from the blood of 63 of 325 Rattus norvegicus and 11 of 92 Rattus rattus from 13 sites in the United States and Portugal. Infection in both Rattus species ranged from 0% (e.g., 0/87) to approximately 60% (e.g., 35/62). A 337-bp fragment of the citrate synthase (gltA) gene amplified by polymerase chain reaction was sequenced from all 74 isolates. Isolates from R. norvegicus were most similar to Bartonella elizabethae, isolated previously from a patient with endocarditis (93%-100% sequence similarity), followed by Bartonella grahamii and other Bartonella species isolated from Old World rodents (Clethrionomys species, Mus musculus, and Rattus species). These data suggest that Rattus species are a reservoir host for pathogenic Bartonella species and are consistent with a hypothesized Old World origin for Bartonella species recovered from Rattus species introduced into the Americas.
从美国和葡萄牙13个地点的325只褐家鼠中的63只以及92只黑家鼠中的11只的血液中分离出了巴尔通体属细菌。两种鼠类的感染率从0%（如0/87）到约60%（如35/62）不等。对通过聚合酶链反应扩增的柠檬酸合酶（gltA）基因的一个337 bp片段进行了测序，所有74株分离株均参与其中。褐家鼠的分离株与先前从一名心内膜炎患者分离出的伊丽莎白巴尔通体最为相似（序列相似性为93%-100%），其次是格雷厄姆巴尔通体和从旧大陆啮齿动物（棕背䶄属物种、小家鼠和家鼠属物种）分离出的其他巴尔通体属物种。这些数据表明，家鼠属物种是致病性巴尔通体属物种的储存宿主，这与从引入美洲的家鼠属物种中分离出的巴尔通体属物种起源于旧大陆的假设一致。
