Duthie M S, Kimber I, Norval M
Department of Medical Microbiology, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, U.K.
Br J Dermatol. 1999 Jun;140(6):995-1009. doi: 10.1046/j.1365-2133.1999.02898.x.
The adverse outcome of increased ultraviolet (UV) irradiation on human health is currently of concern. While many experiments have been carried out in rodent models, fewer have been designed to test the effects of UV exposure in human subjects. This review concentrates on the modulations induced in the human immune system by UV, and outlines changes in antigen presentation by Langerhans cells and macrophages, in the activities of natural killer cells and T cells, and in cytokine regulation. Precautionary measures which might be taken to help protect people against the immunosuppressive action of UV irradiation are considered.
紫外线（UV）辐射增加对人类健康产生的不良后果目前备受关注。虽然已经在啮齿动物模型中进行了许多实验，但设计用于测试紫外线暴露对人类受试者影响的实验较少。本综述集中于紫外线对人类免疫系统的调节作用，并概述了朗格汉斯细胞和巨噬细胞的抗原呈递、自然杀伤细胞和T细胞的活性以及细胞因子调节方面的变化。文中还考虑了可能采取的预防措施，以帮助保护人们免受紫外线辐射的免疫抑制作用。
