Wollheim F A
Department of Rheumatology, Lund University Hospital, Sweden.
Rheum Dis Clin North Am. 1999 May;25(2):417-32, viii. doi: 10.1016/s0889-857x(05)70076-4.
Joint cartilage is a dynamic tissue that reacts to trauma, inflammation, and other insults by attempting to repair its matrix. This reaction results in the release of cartilage macromolecules into the body fluids. Analysis of these fluids has identified a limited number of at least somewhat tissue-specific markers of altered cartilage metabolism. Analyses of serum are less specific and less sensitive than analyses of synovial fluid, but their use as research tools in clinical studies, drug development, and experimental work in animal models is increasing.
关节软骨是一种动态组织，它会通过尝试修复其基质来应对创伤、炎症和其他损伤。这种反应会导致软骨大分子释放到体液中。对这些体液的分析已经确定了数量有限的、至少在一定程度上是软骨代谢改变的组织特异性标志物。血清分析的特异性和敏感性低于滑液分析，但在临床研究、药物开发以及动物模型实验工作中，血清作为研究工具的应用正在增加。
