Konerding M A, Malkusch W, Klapthor B, van Ackern C, Fait E, Hill S A, Parkins C, Chaplin D J, Presta M, Denekamp J
Department of Anatomy, Johannes Gutenberg-University Mainz, Germany.
Br J Cancer. 1999 May;80(5-6):724-32. doi: 10.1038/sj.bjc.6690416.
The vascular architecture of four different tumour cell lines (CaX, CaNT, SaS, HEC-1B) transplanted subcutaneously in mice was examined by means of microvascular corrosion casting in order to determine whether there is a characteristic vascular pattern for different tumour types and whether it differs significantly from two normal tissues, muscle and gut. Three-dimensional reconstructed scanning electron microscope images were used for quantitative measurements. Vessel diameters, intervessel and interbranch distances showed large differences between tumour types, whereas the branching angles were similar. In all tumours, the variability of the vessel diameters was significantly higher than in normal tissue. The quantitative data provide strong evidence for a characteristic vascular network determined by the tumour cells themselves.
通过微血管铸型法研究了皮下移植到小鼠体内的四种不同肿瘤细胞系（CaX、CaNT、SaS、HEC-1B）的血管结构，以确定不同肿瘤类型是否存在特征性血管模式，以及它与肌肉和肠道这两种正常组织是否有显著差异。三维重建扫描电子显微镜图像用于定量测量。肿瘤类型之间的血管直径、血管间和分支间距离显示出很大差异，而分支角度相似。在所有肿瘤中，血管直径的变异性明显高于正常组织。定量数据为肿瘤细胞自身决定的特征性血管网络提供了有力证据。
