Chung T K, Lee D T, Cheung L P, Haines C J, Chang A M
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Sha Tin, NT.
Fertil Steril. 1999 Jun;71(6):1054-9. doi: 10.1016/s0015-0282(99)00128-4.
To compare the efficacy of surgical evacuation of the uterus with medical evacuation using misoprostol in cases of spontaneous abortion.
A prospective, randomized, controlled trial.
A university teaching hospital.
PATIENT(S): Six hundred thirty-five women who aborted spontaneously and who consented to pretreatment randomization.
INTERVENTION(S): Routine surgical evacuation or medical evacuation of the uterus using misoprostol.
MAIN OUTCOME MEASURE(S): Immediate, short-term (2-3 weeks), and medium-term (6 months) medical complications.
RESULT(S): There was a significantly lower incidence of immediate and short-term complications in the group treated with misoprostol compared with the surgically treated group. There were also fewer major complications in the 6 months after treatment in the medically treated group. Approximately 50% of the medically treated group subsequently required surgical evacuation, and these subjects required significantly more analgesia.
CONCLUSION(S): Treatment with misoprostol can reduce the demand for surgical evacuation in cases of spontaneous abortion, and its use is associated with fewer medical complications.
比较在自然流产病例中，子宫手术排空与使用米索前列醇进行药物排空的疗效。
一项前瞻性、随机、对照试验。
一家大学教学医院。
635名自然流产且同意治疗前随机分组的女性。
常规手术排空子宫或使用米索前列醇进行药物排空子宫。
即刻、短期（2 - 3周）和中期（6个月）的医学并发症。
与手术治疗组相比，米索前列醇治疗组即刻和短期并发症的发生率显著更低。药物治疗组在治疗后6个月内的严重并发症也更少。约50%的药物治疗组患者随后需要手术排空，且这些患者需要显著更多的镇痛措施。
米索前列醇治疗可减少自然流产病例中手术排空的需求，且其使用与更少的医学并发症相关。
