与女性血液淋巴系统恶性肿瘤风险相关的职业、环境和生活方式因素。

Occupational, environmental, and life-style factors associated with the risk of hematolymphopoietic malignancies in women.

作者信息

Miligi L, Seniori Costantini A, Crosignani P, Fontana A, Masala G, Nanni O, Ramazzotti V, Rodella S, Stagnaro E, Tumino R, Viganò C, Vindigni C, Vineis P

机构信息

Epidemiology Unit, Center for Study and Prevention of Cancer, Az. Ospedaliera Careggi, Florence, Italy.

出版信息

Am J Ind Med. 1999 Jul;36(1):60-9. doi: 10.1002/(sici)1097-0274(199907)36:1<60::aid-ajim9>3.0.co;2-z.

DOI:10.1002/(sici)1097-0274(199907)36:1<60::aid-ajim9>3.0.co;2-z

PMID:10361588

Abstract

BACKGROUND

The etiology of lymphomas, leukemias, and multiple myeloma is still largely unknown. The known risk factors (ionizing radiation, solvent exposure, pesticide exposure, immunosuppression) explain only a small proportion of the cases that occur.

METHODS

We conducted a multicenter population-based case-control study on hematolymphopoietic malignancies in Italy and interviewed 2,011 women (1,183 cases and 828 controls).

RESULTS

There was a suggestion of a positive association between smoking and the risk of non-Hodgkin's lymphoma + chronic lymphocytic leukemia. A slight increased risk of leukemias was observed among women using permanent hair dye. Housewives were at increased risk for leukemia and multiple myeloma. The risk of non-Hodgkin's lymphomas + chronic lymphocytic leukemia, leukemias, multiple myeloma, and Hodgkin's disease increased among women employed as hairdressers and textile workers. Teachers were at increased risk for non-Hodgkin's lymphomas + chronic lymphocytic leukemia, leukemias, and Hodgkin's disease.

CONCLUSIONS

These results confirm previous associations and may provide additional clues to some determinants of hematolymphopoietic malignancies in women.

摘要

背景

淋巴瘤、白血病和多发性骨髓瘤的病因在很大程度上仍不清楚。已知的风险因素（电离辐射、接触溶剂、接触杀虫剂、免疫抑制）仅能解释所发生病例中的一小部分。

方法

我们在意大利开展了一项基于人群的多中心血液淋巴系统恶性肿瘤病例对照研究，对2011名女性进行了访谈（1183例病例和828名对照）。

结果

有迹象表明吸烟与非霍奇金淋巴瘤+慢性淋巴细胞白血病的风险之间存在正相关。使用永久性染发剂的女性患白血病的风险略有增加。家庭主妇患白血病和多发性骨髓瘤的风险增加。从事美发师和纺织工人职业的女性患非霍奇金淋巴瘤+慢性淋巴细胞白血病、白血病、多发性骨髓瘤和霍奇金病的风险增加。教师患非霍奇金淋巴瘤+慢性淋巴细胞白血病、白血病和霍奇金病的风险增加。