Saleem Rubeena, Ahmad Syed Iqbal, Ahmed Mohammad, Faizi Zareen, Zikr-ur-Rehman Sadia, Ali Muhammad, Faizi Shaheen
Dr. HMI Institute of Pharmacology and Herbal Sciences, Hamdard University, Karachi-74600, Pakistan.
Biol Pharm Bull. 2003 Jan;26(1):41-6. doi: 10.1248/bpb.26.41.
A novel constituent, shamimicin, 1"', 1"""'-bis-2-(3,4-dihydroxyphenyl)-3,4-dihydro-3,7-dihydroxy-5-O-xylopyranosyloxy-2H-1-benzopyran along with lupeol, which possesses potent hypotensive activity, has been isolated from Bombax ceiba stem bark. BCBMM--one of the most active hypotensive fractions has revealed its adverse effects on heart, liver and kidneys of mice at the dose of 1000 mg/kg/d.
从木棉茎皮中分离出一种新型成分沙米米星，即1"', 1"""'-双-2-(3,4-二羟基苯基)-3,4-二氢-3,7-二羟基-5-O-吡喃木糖氧基-2H-1-苯并吡喃，以及具有强效降压活性的羽扇豆醇。最具活性的降压组分之一BCBMM在剂量为1000毫克/千克/天时，对小鼠的心脏、肝脏和肾脏显示出不良影响。
