山楂三萜类化合物对HIV-I蛋白酶的抑制作用。
Inhibitory effect of triterpenes from Crataegus pinatifida on HIV-I protease.
作者信息
Min B S, Jung H J, Lee J S, Kim Y H, Bok S H, Ma C M, Nakamura N, Hattori M, Bae K
出版信息
Planta Med. 1999 May;65(4):374-5. doi: 10.1055/s-2006-960792.
PMID:10364847
Abstract
The methanol extracts of the leaves of Crataegus pinnatifida showed potent inhibitory activities against HIV-1 protease at a concentration of 100 micrograms/ml. The subsequent fractionation and isolation of the extract gave two active compounds. Their structures were identified as uvaol (1) and ursolic acid (2) by spectral data. These active compounds inhibit HIV-1 protease with IC50 values of 5.5 and 8.0 microM, respectively.
摘要
山楂叶的甲醇提取物在浓度为100微克/毫升时对HIV-1蛋白酶显示出强效抑制活性。随后对提取物进行分级分离和分离得到两种活性化合物。通过光谱数据确定它们的结构分别为乌索醇（1）和熊果酸（2）。这些活性化合物对HIV-1蛋白酶的抑制IC50值分别为5.5和8.0微摩尔。
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