Phillips M F, Steer H M, Soldan J R, Wiles C M, Harper P S
Institute of Medical Genetics, University of Wales College of Medicine, Heath Park, Cardiff, UK.
J Neurol. 1999 Apr;246(4):275-82. doi: 10.1007/s004150050346.
Somnolence in myotonic dystrophy (DM) has not been measured using a reliable daytime somnolence scale. The aim of this study was to compare somnolence in DM patients with healthy controls and Charcot-Marie-Tooth disease (CMT) patients using such a scale and to compare this with potential contributory factors. We investigated 35 subjects with adult-onset DM, 16 healthy controls and 13 CMT controls. The Epworth Sleepiness Scale (ESS) was the principal measurement of daytime somnolence. Nocturnal sleep was assessed using a sleep diary. Other assessments measured daytime respiratory function, cognitive function, motor impairment, disability, swallowing capacity and depression. DM and CMT patients had greater daytime sleepiness than unaffected controls. In the DM group significant correlations were found between somnolence and measures of disability, sleep quality and some measures of depression. It was concluded that there is an abnormal level of daytime somnolence in DM, which is partially associated with disability.
目前尚未使用可靠的日间嗜睡量表来测量强直性肌营养不良（DM）患者的嗜睡情况。本研究的目的是使用这样一种量表比较DM患者与健康对照者以及夏科-马里-图斯病（CMT）患者的嗜睡情况，并将其与潜在的促成因素进行比较。我们调查了35例成年发病的DM患者、16例健康对照者和13例CMT对照者。Epworth嗜睡量表（ESS）是日间嗜睡的主要测量指标。使用睡眠日记评估夜间睡眠情况。其他评估包括测量日间呼吸功能、认知功能、运动障碍、残疾情况、吞咽能力和抑郁情况。DM和CMT患者的日间嗜睡程度高于未受影响的对照者。在DM组中，发现嗜睡与残疾程度、睡眠质量以及一些抑郁指标之间存在显著相关性。研究得出结论，DM患者存在异常水平的日间嗜睡，这与残疾情况部分相关。
