Iida S, Harada Y, Ikenoue S, Moriya H
Department of Orthopaedic Surgery, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-0856, Japan.
J Orthop Sci. 1999;4(3):216-22. doi: 10.1007/s007760050096.
Positron emission tomography was used to measure bone marrow blood volume (BBV), an important hemodynamics parameter, in the knee. The subjects were 11 healthy male volunteers (mean age, 23.6 years; range, 21-27 years). The 15O-labelled carbon monooxide (C15O) single-breath inhalation method was used. In the distal femur, regional (r) BBV in the posterior area of the epiphysis (medial, 2. 25 ml/100 cm3 bone marrow; lateral, 2.03 ml/100 cm3) was significantly less than that in the anterior area of the epiphysis (medial, 3.48 ml/100 cm3; lateral, 3.01 ml/100 cm3) and that in the metaphysis-to-distal diaphysis (2.90-3.67 ml/100 cm3). In the proximal tibia, rBBVs in the metaphysis-to-proximal diaphysis (2. 32-2.76 ml/100 cm3) were significantly less than those in the area of the physis (medial, 3.30 ml/100 cm3; lateral, 3.53 ml/100 cm3). These regional differences in rBBV within the knee may be associated with the development of ischemic bone marrow disorders, such as steroid-induced osteonecrosis, in the knee.
正电子发射断层扫描被用于测量膝关节处的骨髓血容量（BBV），这是一个重要的血流动力学参数。研究对象为11名健康男性志愿者（平均年龄23.6岁；年龄范围21 - 27岁）。采用15O标记的一氧化碳（C15O）单次呼吸吸入法。在股骨远端，骨骺后部区域的局部（r）BBV（内侧，2.25 ml/100 cm³骨髓；外侧，2.03 ml/100 cm³）显著低于骨骺前部区域（内侧，3.48 ml/100 cm³；外侧，3.01 ml/100 cm³）以及干骺端至骨干远端区域（2.90 - 3.67 ml/100 cm³）。在胫骨近端，干骺端至骨干近端区域的rBBV（2.32 - 2.76 ml/100 cm³）显著低于生长板区域（内侧，3.30 ml/100 cm³；外侧，3.53 ml/100 cm³）。膝关节内rBBV的这些区域差异可能与膝关节缺血性骨髓疾病（如类固醇诱导的骨坏死）的发生有关。
