Martiat P, Ferrant A, Cogneau M, Bol A, Michel C, Rodhain J, Michaux J L, Sokal G
Br J Haematol. 1987 Jul;66(3):307-10. doi: 10.1111/j.1365-2141.1987.tb06914.x.
Bone marrow blood flow has been assessed using positron emission tomography and the 15O-labelled carbon dioxide steady-state technique. The measurements were performed at the site of the posterior iliac crest. The bone marrow blood flow was 10.0 ml/min/100 cm3 +/- 3.0 (SD) in normal volunteers. It was markedly increased in patients with polycythaemia vera (26.9 +/- 4.6), chronic granulocytic leukaemia (25.2 +/- 3.9) and myelofibrosis (35.1 +/- 7.3). However, bone marrow blood flow did not differ from normal in patients with aplastic anaemia, chronic haemolysis or chronic lymphocytic leukaemia. There was no relationship between bone marrow cellularity and bone marrow blood flow. The data show that bone marrow blood flow is markedly elevated in polycythaemia vera, myelofibrosis and chronic granulocytic leukaemia and suggest that bone marrow cellularity is not a major factor in regulating bone marrow blood flow.
已使用正电子发射断层扫描和15O标记的二氧化碳稳态技术评估了骨髓血流量。测量在髂后嵴部位进行。正常志愿者的骨髓血流量为10.0毫升/分钟/100立方厘米±3.0（标准差）。真性红细胞增多症患者（26.9±4.6）、慢性粒细胞白血病患者（25.2±3.9）和骨髓纤维化患者（35.1±7.3）的骨髓血流量显著增加。然而，再生障碍性贫血、慢性溶血或慢性淋巴细胞白血病患者的骨髓血流量与正常情况无差异。骨髓细胞密度与骨髓血流量之间没有关系。数据表明，真性红细胞增多症、骨髓纤维化和慢性粒细胞白血病患者的骨髓血流量显著升高，提示骨髓细胞密度不是调节骨髓血流量的主要因素。
