Kahn D, Weiner G J, Ben-Haim S, Ponto L L, Madsen M T, Bushnell D L, Watkins G L, Argenyi E A, Hichwa R D
Department of Radiology, University of Iowa College of Medicine, Iowa City.
Blood. 1994 Feb 15;83(4):958-63.
Ten young normal adults had pelvic and lumbar vertebral body bone marrow blood flow examined using [15O]water and positron emission tomography (PET) in a study designed to assess the feasibility and reproducibility of the PET technique for measuring marrow blood flow to various marrow regions. The procedure was well tolerated. Repeated blood flow measurements obtained from two consecutive [15O]water exams on each individual subject were highly reproducible. In addition, there was minimal variation in marrow blood flow from individual to individual and no gender differences were noted. In contrast, mean +/- SD bone marrow blood flows (expressed as milliliters per minute per 100 g) at selected anatomical sites were significantly different and were as follows: lower lumbar vertebral bodies, 17.6 +/- 3.1; most posterior and superior pelvis (conventional site of percutaneous bone marrow biopsy), 14.3 +/- 3.1; and total superior pelvis, 11.1 +/- 2.0. We conclude that PET is a relatively noninvasive, simple, and reproducible technique for measuring bone marrow blood flow. Marrow blood flow is consistent between normal young subjects, but varies significantly between different anatomic regions of the marrow.
在一项旨在评估正电子发射断层扫描（PET）技术测量不同骨髓区域骨髓血流的可行性和可重复性的研究中，10名年轻正常成年人使用[15O]水和正电子发射断层扫描（PET）对骨盆和腰椎椎体骨髓血流进行了检查。该检查耐受性良好。从每个个体受试者的两次连续[15O]水检查中获得的重复血流测量结果具有高度可重复性。此外，个体之间的骨髓血流差异极小，且未发现性别差异。相比之下，选定解剖部位的平均±标准差骨髓血流（以每分钟每100克毫升表示）存在显著差异，具体如下：下腰椎椎体，17.6±3.1；骨盆最后部和上部（经皮骨髓活检的传统部位），14.3±3.1；以及整个骨盆上部，11.1±2.0。我们得出结论，PET是一种相对无创、简单且可重复的测量骨髓血流的技术。正常年轻受试者之间的骨髓血流一致，但骨髓不同解剖区域之间存在显著差异。
