阿朴长春胺酸乙酯的合成。
The synthesis of ethyl apovincaminate.
作者信息
Lörincz C, Szász K, Kisfaludy L
出版信息
Arzneimittelforschung. 1976;26(10a):1907.
PMID:1037211
Abstract
Starting from (+) vincamine (I), simple derivatives of vincaminic acid (II), apovincaminic acid (V) and apovincaminol (VII) were synthetized. Out of these the synthesis of ethyl apovincaminate (Cavinton), as a representative, is described in detail. The water elimination and esterification of II can be carried out in one step.
摘要
从（+）长春胺（I）开始，合成了长春胺酸（II）、阿朴长春胺酸（V）和阿朴长春胺醇（VII）的简单衍生物。其中，作为代表的阿朴长春胺酸乙酯（卡温顿）的合成进行了详细描述。II的脱水和酯化反应可一步完成。
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