Clarke Adam R, Barry Robert J, McCarthy Rory, Selikowitz Mark, Croft Rodney J
Brain and Behaviour Research Institute and Department of Psychology, University of Wollongong, 2522, Wollongong, Australia.
Clin Neurophysiol. 2002 Aug;113(8):1191-8. doi: 10.1016/s1388-2457(02)00147-5.
This study investigated electroencephalographic (EEG) differences between good and poor responders to methylphenidate in boys with the Inattentive type of Attention-Deficit/Hyperactivity Disorder (ADHD).
Twenty good and 15 poor responders to methylphenidate, based on the results of a continuous performance task, and 35 age- and sex-matched control subjects, participated in this study. EEG was recorded from 21 sites during an eyes-closed resting condition and Fourier transformed to provide estimates for total power, and absolute and relative power in the delta, theta, alpha and beta bands, and for the theta/alpha and theta/beta ratios.
EEG differences were found between the ADHD children and controls which were compatible with previous literature on the Inattentive type. Differences were also found between the good and poor responders to methylphenidate.
Good responders had EEG profiles that suggested that they were more cortically hypoaroused than poor responders.
本研究调查了注意力缺陷/多动障碍（ADHD）注意力不集中型男孩中，对哌甲酯反应良好者与反应不佳者之间的脑电图（EEG）差异。
根据连续操作任务的结果，选取20名对哌甲酯反应良好者、15名反应不佳者，以及35名年龄和性别匹配的对照受试者参与本研究。在闭眼休息状态下，从21个部位记录脑电图，并进行傅里叶变换，以提供总功率、δ波、θ波、α波和β波频段的绝对和相对功率，以及θ/α和θ/β比值的估计值。
ADHD儿童与对照组之间的脑电图差异与先前关于注意力不集中型的文献一致。对哌甲酯反应良好者与反应不佳者之间也存在差异。
反应良好者的脑电图特征表明，他们比反应不佳者的皮质唤醒水平更低。
