Deleyiannis F W, Weymuller E A, Coltrera M D, Futran N
Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, USA.
Head Neck. 1999 Jul;21(4):319-24. doi: 10.1002/(sici)1097-0347(199907)21:4<319::aid-hed5>3.0.co;2-h.
The purpose of this study was to determine the functional disabilities and overall quality of life (QOL) of patients successfully treated (ie, without evidence of disease at two years) for laryngeal or hypopharyngeal cancer by a total laryngectomy.
The University of Washington QOL questionnaire was administered to 10 patients prior to laryngectomy, at one year postlaryngectomy, and at two years postlaryngectomy.
Postlaryngectomy QOL scores were not significantly different from prelaryngectomy scores. In all QOL domains the severity of functional disability was not significantly correlated with its importance. Ninety percent of patients (9/10) reported that compared with one year prior to the diagnosis of cancer their general health was the same or better at two years postlaryngectomy. Seventy percent of patients (7/10) reported having a good to excellent overall QOL.
Though the loss of voice is disabling, the functional limitations caused by a laryngectomy do not necessarily translate into a worse overall QOL. Future research is needed to determine whether the importance of individual QOL domains changes as patients adjust to the experience of having and surviving cancer.
本研究的目的是确定接受全喉切除术成功治疗(即两年内无疾病证据)的喉癌或下咽癌患者的功能障碍和总体生活质量(QOL)。
对10例患者在喉切除术前、喉切除术后1年和喉切除术后2年进行华盛顿大学生活质量问卷的调查。
喉切除术后的生活质量评分与喉切除术前的评分无显著差异。在所有生活质量领域,功能障碍的严重程度与其重要性无显著相关性。90%的患者(9/10)报告称,与癌症诊断前一年相比,喉切除术后两年他们的总体健康状况相同或更好。70%的患者(7/10)报告总体生活质量良好至优秀。
虽然失音会导致功能丧失,但喉切除术引起的功能限制并不一定会导致总体生活质量变差。需要进一步的研究来确定随着患者适应患癌和抗癌经历,各个生活质量领域的重要性是否会发生变化。