Lataye R, Campo P, Loquet G
Institut National de Recherche et de Sécurité, Vandoeuvre, France.
Neurotoxicol Teratol. 1999 May-Jun;21(3):267-76. doi: 10.1016/s0892-0362(98)00057-9.
To identify the frequency range most sensitive to toluene-induced auditory damage, the auditory function of adult Long-Evans rats exposed to 1750 ppm of toluene (6 h/day, 5 days/week, 4 weeks), was tested by recording auditory-evoked potentials directly from the round window of the cochlea. The present electrocochleographic findings do not support a specific mid- to high-frequency loss of auditory sensitivity. On the contrary, the electrophysiologic data, obtained for audiometric frequencies ranging from 2 to 32 kHz, showed a hearing deficit not only in the mid-frequency region (12-16 kHz), but also in the mid-low-frequency region (3-4 kHz). Actually, the effect of toluene was independent of the frequency in our experimental conditions. Histological analysis was consistent with electrophysiologic data because a broad loss of outer hair cells occurred in both mid- and mid-apical coil of the organ of Corti.
为了确定对甲苯诱导的听觉损伤最敏感的频率范围，通过直接从耳蜗圆窗记录听觉诱发电位，对暴露于1750 ppm甲苯（每天6小时，每周5天，共4周）的成年Long-Evans大鼠的听觉功能进行了测试。目前的耳蜗电图结果不支持听觉敏感性在特定的中高频范围内丧失。相反，在2至32 kHz的听力计频率下获得的电生理数据显示，不仅在中频区域（12 - 16 kHz），而且在中低频区域（3 - 4 kHz）都存在听力缺陷。实际上，在我们的实验条件下，甲苯的影响与频率无关。组织学分析与电生理数据一致，因为在柯蒂氏器的中圈和顶圈都出现了广泛的外毛细胞损失。
