Campo P, Lataye R, Cossec B, Placidi V
Institut National de Recherche et de Sécurité (I.N.R.S.), Vandoeuvre, France.
Neurotoxicol Teratol. 1997 Mar-Apr;19(2):129-40. doi: 10.1016/s0892-0362(96)00214-0.
Inhaled toluene (from 1000 to 2000 ppm, 6 h/day, 5 days/week, 4 weeks) is anototoxic solvent that severely damaged the cochlea in adult Long-Evans rats. Auditory function was tested by recording near field potentials from the inferior colliculus. Surprisingly, the electrophysiologic results did not reflect all the cochlear damage observed by histology. Loss of outer hair cells of the organ of Corti occurred in all toluene-treated rats in middle and mid-apical turns, whereas the basal turn of the cochlea was fairly well preserved. The third row of outer hair cells was more injured than the second row, which itself was more injured than the first row. The locations of the cochlear lesions are reported in the present study with regard to the toluene dose.
吸入甲苯（浓度为1000至2000 ppm，每天6小时，每周5天，共4周）是一种耳毒性溶剂，会严重损害成年Long-Evans大鼠的耳蜗。通过记录下丘的近场电位来测试听觉功能。令人惊讶的是，电生理结果并未反映出组织学观察到的所有耳蜗损伤情况。所有接受甲苯处理的大鼠在中回和中顶回的柯蒂氏器外毛细胞均发生丢失，而耳蜗的基部则保存得相当完好。第三排外毛细胞比第二排受损更严重，而第二排比第一排受损更严重。本研究报告了耳蜗病变部位与甲苯剂量的关系。
