Weinberger A W, Knabben H, Solbach U, Wolf S
Augenklinik der Med Fak der RWTH Aachen, Germany.
Br J Ophthalmol. 1999 Feb;83(2):168-72. doi: 10.1136/bjo.83.2.168.
To determine whether indocyanine green (ICG) guided laser photocoagulation of occult choroidal neovascularisations (OCNV) is beneficial for patients with occult choroidal neovascularisation secondary to age related macular degeneration (AMD).
A prospective pilot study was performed in 21 eyes with OCNV secondary to AMD that could be identified extrafoveolarly or juxtafoveolarly in an early ICG angiographic study. Laser photocoagulation was applied to the neovascular membrane identified in the early ICG angiographic study.
Visual acuity ranged from 20/400 to 20/20 (logMAR 0.54 (SD 0.29) before and hand movements and 20/30 (logMAR 0.81 (0.69)) at the last follow up after laser photocoagulation. During the follow up (30 (13) months) vision improved in four eyes (two lines), in seven eyes the initial visual acuity could be stabilised (two lines), in five eyes vision dropped moderately (three to five lines), and in five eyes vision decreased severely (six or more lines). Recurrences (seven patients) or persistent CNV (six patients) was observed in 13 patients.
This preliminary study of ICG guided laser photocoagulation of occult extrafoveal and juxtafoveal choroidal neovascularisations suggests that this technique may improve the visual prognosis of these patients. Further prospective controlled studies are necessary to confirm these data.
确定吲哚菁绿（ICG）引导下对隐匿性脉络膜新生血管（OCNV）进行激光光凝治疗对年龄相关性黄斑变性（AMD）继发隐匿性脉络膜新生血管患者是否有益。
对21只患有AMD继发OCNV的眼睛进行前瞻性初步研究，这些眼睛在早期ICG血管造影研究中可在黄斑中心凹外或黄斑中心凹旁被识别。对早期ICG血管造影研究中识别出的新生血管膜进行激光光凝治疗。
视力范围从20/400至20/20（激光光凝前logMAR为0.54（标准差0.29），手动视力，最后一次随访时为20/30（logMAR为0.81（0.69））。在随访期间（30（13）个月），4只眼睛视力提高（两行），7只眼睛初始视力得以稳定（两行），5只眼睛视力中度下降（三至五行），5只眼睛视力严重下降（六行或更多行）。13例患者中观察到复发（7例）或持续性脉络膜新生血管（6例）。
这项关于ICG引导下对隐匿性黄斑中心凹外和黄斑中心凹旁脉络膜新生血管进行激光光凝治疗的初步研究表明，该技术可能改善这些患者的视觉预后。需要进一步的前瞻性对照研究来证实这些数据。
