沙门氏菌与肠道黏膜相互作用的分子基础。
Molecular basis of the interaction of Salmonella with the intestinal mucosa.
作者信息
Darwin K H, Miller V L
机构信息
Departments of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
出版信息
Clin Microbiol Rev. 1999 Jul;12(3):405-28. doi: 10.1128/CMR.12.3.405.
Abstract
Salmonella is one of the most extensively characterized bacterial pathogens and is a leading cause of bacterial gastroenteritis. Despite this, we are only just beginning to understand at a molecular level how Salmonella interacts with its mammalian hosts to cause disease. Studies during the past decade on the genetic basis of virulence of Salmonella have significantly advanced our understanding of the molecular basis of the host-pathogen interaction, yet many questions remain. In this review, we focus on the interaction of enterocolitis-causing salmonellae with the intestinal mucosa, since this is the initiating step for most infections caused by Salmonella. Animal and in vitro cell culture models for the interaction of these bacteria with the intestinal epithelium are reviewed, along with the bacterial genes that are thought to affect this interaction. Lastly, recent studies on the response of epithelial cells to Salmonella infection and how this might promote diarrhea are discussed.
摘要
沙门氏菌是特征描述最为广泛的细菌病原体之一，也是细菌性肠胃炎的主要病因。尽管如此，我们才刚刚开始在分子水平上了解沙门氏菌如何与哺乳动物宿主相互作用从而引发疾病。过去十年间关于沙门氏菌毒力遗传基础的研究显著推进了我们对宿主 - 病原体相互作用分子基础的理解，但仍有许多问题存在。在这篇综述中，我们聚焦于引起小肠结肠炎的沙门氏菌与肠黏膜的相互作用，因为这是沙门氏菌引发的大多数感染的起始步骤。本文综述了这些细菌与肠上皮相互作用的动物和体外细胞培养模型，以及被认为影响这种相互作用的细菌基因。最后，讨论了上皮细胞对沙门氏菌感染的反应以及这可能如何促进腹泻的近期研究。
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