Tohgi H, Abe T, Yamazaki K, Murata T, Ishizaki E, Isobe C
Department of Neurology, Iwate Medical University, Morioka, Japan.
Ann Neurol. 1999 Jul;46(1):129-31. doi: 10.1002/1531-8249(199907)46:1<129::aid-ana21>3.0.co;2-y.
To investigate the significance of peroxynitrite-mediated oxidative damage in the pathogenesis of sporadic amyotrophic lateral sclerosis (SALS), the concentrations of 3-nitrotyrosine and tyrosine in the cerebrospinal fluid (CSF) of patients with SALS were determined. The concentration of 3-nitrotyrosine and the 3-nitrotyrosine/ tyrosine ratio in patients with SALS were approximately seven times those of controls. Thus, the present findings in living patients provide in vivo evidence for a possible role of peroxynitrite, a mediator of oxidative stress, and increased nitration of tyrosine residues in the pathogenesis of SALS.
