Sutters K A, Shaw B A, Gerardi J A, Hebert D
Surgical Services, Valley Children's Hospital, Madera, California, USA.
Am J Orthop (Belle Mead NJ). 1999 Jun;28(6):351-8.
The purpose of this prospective, randomized, double-blind, placebo-controlled clinical study was to determine whether the administration of intravenous ketorolac, coadministered with morphine patient-controlled analgesia (PCA), demonstrates an opioid-sparing effect, provides improved analgesia, and reduces the incidence of opioid-induced side effects in children after orthopedic surgery. The findings of enhanced analgesia with decreased opioid use suggest that coadministration of ketorolac with morphine PCA is beneficial for the treatment of pain in children after orthopedic surgery.
这项前瞻性、随机、双盲、安慰剂对照的临床研究的目的是确定静脉注射酮咯酸与吗啡患者自控镇痛（PCA）联合使用时，是否能显示出阿片类药物节省效应、提供更好的镇痛效果，并降低骨科手术后儿童阿片类药物引起的副作用发生率。增强镇痛效果且减少阿片类药物使用的研究结果表明，酮咯酸与吗啡PCA联合使用对治疗骨科手术后儿童的疼痛有益。
