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日本前胡中香豆素对单胺氧化酶的抑制活性。

Inhibitory activity of monoamine oxidase by coumarins from Peucedanum japonicum.

作者信息

Huong D T, Choi H C, Rho T C, Lee H S, Lee M K, Kim Y H

机构信息

College of Pharmacy, Chungnam National University, Taejon, Korea.

出版信息

Arch Pharm Res. 1999 Jun;22(3):324-6. doi: 10.1007/BF02976373.

DOI:10.1007/BF02976373
PMID:10403141
Abstract

Four coumarins were isolated from chloroform extract of the root of Peucedanum japonicum and identified as praeruptorin A(1), xanthotoxin (2), psoralen (3) and bergapten (4) on the basis of spectroscopic methods. The inhibitory activities of these coumarins on monoamine oxidase prepared by mouse brain were tested. The IC50 values of them were shown to be 27.4 microM (1), 40.7 microM (2), 35.8 microM (3), and 13.8 microM (4), in vitro.

摘要

从日本前胡根的氯仿提取物中分离出四种香豆素，并通过光谱方法鉴定为前胡素A（1）、花椒毒素（2）、补骨脂素（3）和佛手柑内酯（4）。测试了这些香豆素对小鼠脑制备的单胺氧化酶的抑制活性。它们在体外的IC50值分别为27.4微摩尔（1）、40.7微摩尔（2）、35.8微摩尔（3）和13.8微摩尔（4）。

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