Hasegawa T, Ito K, Ueno S, Kumamoto S, Ando Y, Yamada A, Nomoto K, Yasunobu Y
Research Laboratories, Chlorella Industries Co., Ltd, Chikugo City, Fukuoka, Japan.
Int J Immunopharmacol. 1999 May;21(5):311-23. doi: 10.1016/s0192-0561(99)00013-2.
Hot water extract of Chlorella vulgaris (CVE) is a biological response modifier (BRM) which enhances resistance to Listeria monocytogenes through augmentation of helper T cell type 1 (Thl) responses producing gamma-interferon (gammaIFN). We show here that oral administration of CVE in mice suppressed the production of immunoglobulin (Ig)E against casein antigen accompanied by increased gammaIFN and IL-12 mRNA expression. Oral administration of CVE enhanced Thl response to casein in the spleen of casein immunized mice. CVE may be useful for prevention of allergic diseases with a predominant Th2 response.
普通小球藻热水提取物（CVE）是一种生物反应调节剂（BRM），它通过增强产生γ干扰素（γIFN）的1型辅助性T细胞（Th1）反应来增强对单核细胞增生李斯特菌的抵抗力。我们在此表明，给小鼠口服CVE可抑制针对酪蛋白抗原的免疫球蛋白（Ig）E的产生，同时γIFN和IL-12 mRNA表达增加。给酪蛋白免疫的小鼠口服CVE可增强脾脏中对酪蛋白的Th1反应。CVE可能有助于预防以Th2反应为主的过敏性疾病。
