Schmidt D, Zehender M
Universitäts-Augenklinik Freiburg.
Ophthalmologe. 1999 Apr;96(4):264-6. doi: 10.1007/s003470050403.
Infectious endocarditis can lead to embolic arterial retinal occlusions. Which therapy is indicated?
A 33-year-old man suddenly became blind in his left eye as the result of a central retinal artery occlusion (CRAO). This occurred during high-dosage treatment for infectious endocarditis that had been diagnosed 3 weeks earlier. The echocardiogram showed distinct vegetation and an abscess on the aortic valve. The CRAO together with the ultrasound findings was considered an absolute indication for surgery of the aortic valve. During this emergency operation, a 2 cm deep abscess cavity was found between the mitral and aortic valves. After removal of the abscess, together with the infected valve, a prosthetic valve was inserted. Following the operation, the patient made an uneventful recovery. The antibiotic treatment was continued for several months. The left eye remained sightless. No recurrence of infectious endocarditis occurred during the follow-up of 2 1/4 years. A branch retinal arterial occlusion occurred in the right eye of a 35-year-old man who had suffered from chronic infectious endocarditis for several months. Insufficiency of more than one valve had been diagnosed on several occasions. The patient, a drug-addict, had refused surgical treatment on each occasion. After 3 months, the right eye became completely blind owing to CRAO. Following high-dosage treatment with antibiotics, the infectious endocarditis was healed. The right eye remained blind. One year later the patient died.
Retinal arterial occlusion of embolic origin in a patient with infectious endocarditis is an indication for immediate medical and/or surgical treatment. This is of particular importance if there is ultrasound evidence of an abscess in the valve area.
感染性心内膜炎可导致动脉性视网膜栓塞性阻塞。应采用何种治疗方法?
一名33岁男性因视网膜中央动脉阻塞(CRAO)突然左眼失明。这发生在3周前诊断为感染性心内膜炎的高剂量治疗期间。超声心动图显示主动脉瓣有明显的赘生物和脓肿。CRAO加上超声检查结果被认为是主动脉瓣手术的绝对指征。在这次急诊手术中,在二尖瓣和主动脉瓣之间发现了一个2厘米深的脓肿腔。切除脓肿和感染的瓣膜后,植入了人工瓣膜。术后,患者恢复顺利。抗生素治疗持续了几个月。左眼仍然失明。在2年零3个月的随访期间,感染性心内膜炎未复发。一名患有慢性感染性心内膜炎数月的35岁男性右眼发生了视网膜分支动脉阻塞。多次诊断出不止一个瓣膜功能不全。该患者为吸毒者,每次都拒绝手术治疗。3个月后,右眼因CRAO完全失明。经过大剂量抗生素治疗,感染性心内膜炎痊愈。右眼仍然失明。1年后患者死亡。
感染性心内膜炎患者发生的栓塞性视网膜动脉阻塞是立即进行药物和/或手术治疗的指征。如果瓣膜区域有脓肿的超声证据,这一点尤为重要。