Lass A, Kwong L, Sohal R S
Department of Biological Sciences, Southern Methodist University, Dallas, TX 75275, USA.
Biofactors. 1999;9(2-4):199-205. doi: 10.1002/biof.5520090215.
The main objective of this study was to determine the nature of the relationship between aging and mitochondrial coenzyme Q (CoQ) content. Mitochondria in the heart, skeletal muscle, kidney and brain of the mouse varied in both the amount of total CoQ (CoQ9 + CoQ10) content as well as in the ratio of the CoQ9 to CoQ10. CoQ content declined with age only in the skeletal muscle. Caloric restriction (CR) resulted in an increase in the amount of CoQ9 in skeletal muscle mitochondria. This effect was partially reversible upon termination of the caloric restriction regimen. Results suggest that a decrease in mitochondrial CoQ content is an integral aspect of aging in skeletal muscle.
本研究的主要目的是确定衰老与线粒体辅酶Q（CoQ）含量之间关系的本质。小鼠心脏、骨骼肌、肾脏和大脑中的线粒体，其总CoQ（CoQ9 + CoQ10）含量以及CoQ9与CoQ10的比例均有所不同。仅在骨骼肌中，CoQ含量随年龄增长而下降。热量限制（CR）导致骨骼肌线粒体中CoQ9含量增加。在热量限制方案终止后，这种效应部分可逆。结果表明，线粒体CoQ含量的降低是骨骼肌衰老的一个内在方面。
