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钙浓度、乙酸盐和丙酸盐对人体远端结肠钙吸收的影响。

Effects of calcium concentration, acetate, and propionate on calcium absorption in the human distal colon.

作者信息

Trinidad T P, Wolever T M, Thompson L U

机构信息

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada.

出版信息

Nutrition. 1999 Jul-Aug;15(7-8):529-33. doi: 10.1016/s0899-9007(99)00110-0.

Abstract

Previous studies have shown that the short-chain fatty acids acetate (Ac) and propionate (Pr) enhance the absorption of calcium (Ca) in the rectum and distal colon of humans, with Pr being more effective than Ac. To investigate the effect of Ac and Pr on the kinetics of Ca absorption from the human rectum and distal colon, six healthy subjects were studied. Solutions containing various concentrations of CaCl2.H2O with 56.3 mmol/L Ac, Pr, or NaCl were rectally infused to each subject. Rectal fluid was sampled at the end of the infusion (0 min), and 30 min later colonic contents were collected. Ca absorption for all treatments increased linearly with Ca concentration. For Ca + NaCl, the slope of regression line was 62 mumol.mmol-1.L Ca. With Ac + Ca, the slope of Ca absorption increased significantly to 113 mumol.mmol-1.L Ca, and with Pr + Ca, the slope increased to 159 mumol.mmol-1.L (P = 0.043 versus Ac + Ca) Ac and Pr absorption were increased by Ca. The data suggest that, over a physiologic range of Ca concentration, in the absence or presence of Ac and Pr, Ca is absorbed in the human rectum and distal colon by a non-saturable diffusion process, and that Ca absorption is enhanced by Ac and Pr. The data also suggest that both Ac and Pr absorption is stimulated by Ca.

摘要

先前的研究表明,短链脂肪酸乙酸盐(Ac)和丙酸盐(Pr)可增强人体直肠和结肠远端对钙(Ca)的吸收,其中Pr的效果比Ac更显著。为了研究Ac和Pr对人体直肠和结肠远端钙吸收动力学的影响,对6名健康受试者进行了研究。将含有不同浓度CaCl2·H2O以及56.3 mmol/L Ac、Pr或NaCl的溶液经直肠注入每位受试者体内。在注入结束时(0分钟)采集直肠液,30分钟后收集结肠内容物。所有处理方式下的钙吸收均随钙浓度呈线性增加。对于Ca + NaCl组,回归线斜率为62 μmol·mmol-1·L Ca。对于Ac + Ca组,钙吸收斜率显著增加至113 μmol·mmol-1·L Ca,而对于Pr + Ca组,斜率增加至159 μmol·mmol-1·L(与Ac + Ca组相比,P = 0.043)。钙可增加Ac和Pr的吸收。数据表明,在生理钙浓度范围内,无论有无Ac和Pr,人体直肠和结肠远端的钙吸收均通过非饱和扩散过程进行,且Ac和Pr可增强钙的吸收。数据还表明,钙可刺激Ac和Pr的吸收。

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