Kurmanavicius J, Wright E M, Royston P, Zimmermann R, Huch R, Huch A, Wisser J
Department of Obstetrics, Zurich University Hospital, Switzerland.
Br J Obstet Gynaecol. 1999 Feb;106(2):136-43. doi: 10.1111/j.1471-0528.1999.tb08213.x.
To create reliable reference ranges and calculate Z scores for fetal abdomen and femur ultrasound biometry using a large sample size which is evenly distributed from 12 to 42 weeks of pregnancy.
A prospective, cross-sectional study.
Obstetric clinics (outpatient and delivery units) at the University Hospital of Zurich.
The study data were obtained from 6557 pregnant women.
Only the first ultrasound examination between 12 and 42 weeks of each fetus with certainly established gestational age was used for analysis. No exclusions were made on the grounds of small-for-date birthweight, prematurity or other events several weeks after the examination. Separate regression models were fitted to estimate the mean and standard deviation at each gestational age for each parameter.
A total of 5807 mean abdominal diameters and abdominal circumferences were derived from fetal transverse and anterio-posterior fetal abdominal diameter measurements. Fetal femur length was measured in 5860 instances. The charts, tables and regression formulae of the biometrical measurements are presented. A comparison of our charts with others showed no significant difference. Only Merz's centiles for abdominal biometry were lower and for femur length higher than ours. An application to calculate Z scores was developed using Excel (Microsoft Corporation, USA); the macros are presented in detail in the Figure 6 footnote.
We have presented centile charts, tables and formulae for fetal abdominal diameter and circumference and femur length derived from a large and minimally selected sample size in a carefully designed cross-sectional study. Complete tables and regression formulae to calculate reference ranges and Z scores are presented to use in computer-aided evaluation of fetal ultrasound biometry.
利用妊娠12至42周均匀分布的大样本量，创建可靠的参考范围并计算胎儿腹部和股骨超声生物测量的Z分数。
一项前瞻性横断面研究。
苏黎世大学医院的产科诊所（门诊和分娩科室）。
研究数据来自6557名孕妇。
仅使用每个胎儿在妊娠12至42周之间首次进行的、孕周确定的超声检查进行分析。不基于小于胎龄出生体重、早产或检查后数周的其他情况进行排除。拟合单独的回归模型以估计每个参数在每个孕周的均值和标准差。
通过胎儿腹部横径和前后径测量得出总共5807个平均腹径和腹围。测量了5860例胎儿股骨长度。给出了生物测量的图表、表格和回归公式。将我们的图表与其他图表进行比较，未发现显著差异。只有Merz的腹部生物测量百分位数比我们的低，股骨长度百分位数比我们的高。使用Excel（美国微软公司）开发了一个计算Z分数的应用程序；宏在图6脚注中有详细介绍。
在一项精心设计的横断面研究中，我们给出了基于大量且筛选最少的样本量得出的胎儿腹径、腹围和股骨长度的百分位数图表、表格和公式。提供了完整的表格和回归公式以计算参考范围和Z分数，用于胎儿超声生物测量的计算机辅助评估。
