Engmann L, Maconochie N, Bekir J S, Jacobs H S, Tan S L
The London Women's Clinic, Canada.
Br J Obstet Gynaecol. 1999 Feb;106(2):165-70. doi: 10.1111/j.1471-0528.1999.tb08217.x.
To provide an assessment of pregnancy and live birth probabilities for women presenting for in vitro fertilisation treatment for the first time, when committed in advance to have up to three cycles of treatment in one year.
Up to three cycles of in vitro fertilisation within one year, committed in advance.
A tertiary referral centre for assisted reproduction.
Two hundred and thirty-two women, undergoing a total of 536 cycles of in vitro fertilisation or intracytoplasmic sperm injection between August 1993 and December 1995.
Analysis of cumulative clinical pregnancy and live birth rates for women having IVF treatment for the first time and undertaking a three-cycle package, using the life-table approach.
Cumulative clinical pregnancy and live birth rates.
The cumulative probabilities of clinical pregnancy and live birth after two cycles of treatment were 38.2% and 33.2%, respectively, compared with 54.2% and 48.2%, respectively, after three cycles of treatment. Cumulative clinical pregnancy and live birth rates after three cycles of treatment for women up to the age of 40 years were 57.8% and 51.3%, respectively. Cumulative clinical pregnancy and live birth rates declined with increasing age (P = 0.02 and P= 0.01, respectively).
The three-cycle package encourages couples to have multiple treatment cycles, thereby improving their ultimate chances of a live birth. The cumulative clinical pregnancy and live birth rates after such a package provide a more realistic assessment of overall and age-specific success rates after multiple treatment cycles.
评估首次接受体外受精治疗且预先承诺在一年内进行最多三个周期治疗的女性的妊娠和活产概率。
预先承诺在一年内进行最多三个周期的体外受精。
一家三级辅助生殖转诊中心。
1993年8月至1995年12月期间，232名女性共接受了536个周期的体外受精或卵胞浆内单精子注射治疗。
采用生命表法分析首次接受体外受精治疗并进行三个周期套餐治疗的女性的累积临床妊娠率和活产率。
累积临床妊娠率和活产率。
两个周期治疗后的临床妊娠累积概率和活产累积概率分别为38.2%和33.2%，三个周期治疗后分别为54.2%和48.2%。40岁及以下女性三个周期治疗后的累积临床妊娠率和活产率分别为57.8%和51.3%。累积临床妊娠率和活产率随年龄增加而下降（分别为P = 0.02和P = 0.01）。
三个周期套餐鼓励夫妇进行多个治疗周期，从而提高他们最终活产的机会。这样一个套餐后的累积临床妊娠率和活产率为多个治疗周期后的总体成功率和年龄特异性成功率提供了更现实的评估。
