慢性梗阻性脑积水患者正常脑白质的磁化传递测量
Magnetization transfer measurements in normal-appearing cerebral white matter in patients with chronic obstructive hydrocephalus.
作者信息
Hähnel S, Münkel K, Jansen O, Heiland S, Reidel M, Freund M, Aschoff A, Sartor K
机构信息
Department of Neuroradiology, University of Heidelberg Medical School, Germany.
出版信息
J Comput Assist Tomogr. 1999 Jul-Aug;23(4):516-20. doi: 10.1097/00004728-199907000-00004.
PURPOSE
The purpose of this work was to assess the presence of subtle changes in normal-appearing white matter on T2-weighted MR images in patients with chronic obstructive hydrocephalus using magnetization transfer (MT) measurements.
METHOD
In 12 patients with chronic obstructive hydrocephalus, MT ratios (MTRs) of normal-appearing rostral (PR) and caudal (PC) periventricular white matter, of the genu (CG) and the splenium (CS) of the corpus callosum, and of the thalamus (TH) were measured and compared with those of 16 healthy control subjects.
RESULTS
We found a significantly lower MTR in chronic obstructive hydrocephalus than in the normal group for PR, PC, CG, and CS but not for TH.
CONCLUSION
Our study shows that MT measurements give additional information that cannot be gained by conventional SE MRI, suggesting that chronic obstructive hydrocephalus is associated with diffuse white matter damage that also affects normal-appearing cerebral white matter.
目的
本研究旨在利用磁化传递（MT）测量技术，评估慢性梗阻性脑积水患者T2加权磁共振图像上正常表现的白质中细微变化的存在情况。
方法
对12例慢性梗阻性脑积水患者进行测量，测定其正常表现的脑室旁白质前部（PR）和后部（PC）、胼胝体膝部（CG）和压部（CS）以及丘脑（TH）的MT比率（MTR），并与16名健康对照者的相应部位进行比较。
结果
我们发现，慢性梗阻性脑积水患者PR、PC、CG和CS部位的MTR显著低于正常组，但TH部位无此差异。
结论
我们的研究表明，MT测量可提供传统自旋回波（SE）磁共振成像无法获得的额外信息，提示慢性梗阻性脑积水与弥漫性白质损伤有关，这种损伤也累及正常表现的脑白质。
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