Premalatha B, Sachdanandam P
Department of Medical Biochemistry, Dr. A.L.M.P-G I.B.M.S., University of Madras, Chennai, India.
J Ethnopharmacol. 1999 Aug;66(2):131-9. doi: 10.1016/s0378-8741(99)00029-x.
The antioxidant defence system which plays a critical role in carcinogenesis is severely altered in aflatoxin B1 induced hepatocellular carcinoma conditions. In order to assess the antitumour activity of Semecarpus anacardium nut extract, a flavonoid containing drug, non-enzymic antioxidant levels were analysed in control and experimental animals. Plasma was analysed for uric acid, vitamin E and vitamin C. Glutathione, total thiols, non-protein thiols, vitamin E, vitamin C and cytochrome P450 were estimated in liver and kidney homogenates. Depletion of all these antioxidants were recorded in cancer conditions. These deleterious effects are controlled by the administration of Semecarpus anacardium nut extract. Following drug administration, there was a marked increase in antioxidant levels and a dramatic elevation in cytochrome P450 content. It can be concluded that the observed anticancer property of Semecarpus anacardium nut extract may also be explained by its strong antioxidant capacity and capability to induce the in vivo antioxidant system.
在黄曲霉毒素B1诱导的肝细胞癌条件下，在致癌过程中起关键作用的抗氧化防御系统会发生严重改变。为了评估含有黄酮类药物的印楝坚果提取物的抗肿瘤活性，分析了对照动物和实验动物的非酶抗氧化剂水平。检测了血浆中的尿酸、维生素E和维生素C。测定了肝和肾匀浆中的谷胱甘肽、总硫醇、非蛋白硫醇、维生素E、维生素C和细胞色素P450。在癌症条件下记录到所有这些抗氧化剂的消耗。印楝坚果提取物的给药可控制这些有害影响。给药后，抗氧化剂水平显著增加，细胞色素P450含量急剧升高。可以得出结论，印楝坚果提取物所观察到的抗癌特性也可能归因于其强大的抗氧化能力和诱导体内抗氧化系统的能力。
