Orem A, Cimşit G, Değer O, Orem C, Vanizor B
Department of Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Clin Chim Acta. 1999 Jun 15;284(1):81-8. doi: 10.1016/s0009-8981(99)00062-5.
Psoriasis is associated with changes in plasma lipid and lipoproteins, which may play a role in the development of occlusive vascular disease. The oxidation of low-density lipoprotein (LDL) is considered a key event in the development and progression of atherosclerosis. Autoantibodies against oxidized LDL (auAb-oxLDL) may contribute to understanding the relationship between oxidative processes and development of atherosclerosis. Thirty-three patients with psoriasis and 30 matched control subjects were investigated. LDL oxidation was evaluated as the presence of autoantibodies against LDL oxidatively modified with Cu++, by an ELISA system in the patients and control sera. AuAb-ox LDL levels of the patients were found to be significantly increased compared with a control group. 42% of the patients and 3.3% of the control subjects had higher auAb-ox LDL levels than the cut-off point (352 mU/ml). The levels of auAb-ox LDL were found to be correlated with PASI score (r = 0.67, p < 0.01). Also, The antibody level was found to be correlated with polymorphonuclear elastase and alpha-1 antitrypsin levels (r = 0.58, p < 0.05; r = 0.51, p < 0.05, respectively). It was concluded that increased levels of auAb-oxLDL in the psoriatic patients may be a consequence of the interaction between imbalance of oxidant-antioxidant system and lipoproteins, and the measurement of auAb-oxLDL in the patients may mirror in vivo occurrence of oxidative processes.
银屑病与血浆脂质和脂蛋白的变化有关，这些变化可能在闭塞性血管疾病的发生中起作用。低密度脂蛋白（LDL）的氧化被认为是动脉粥样硬化发生和发展的关键事件。抗氧化型LDL自身抗体（auAb-oxLDL）可能有助于理解氧化过程与动脉粥样硬化发展之间的关系。对33例银屑病患者和30例匹配的对照受试者进行了研究。通过ELISA系统检测患者和对照血清中针对用Cu++氧化修饰的LDL的自身抗体，以此评估LDL氧化情况。发现患者的auAb-ox LDL水平与对照组相比显著升高。42%的患者和3.3%的对照受试者的auAb-ox LDL水平高于临界值（352 mU/ml）。发现auAb-ox LDL水平与银屑病面积和严重程度指数（PASI）评分相关（r = 0.67，p < 0.01）。此外，还发现抗体水平与多形核弹性蛋白酶和α-1抗胰蛋白酶水平相关（分别为r = 0.58，p < 0.05；r = 0.51，p < 0.05）。得出的结论是，银屑病患者中auAb-oxLDL水平升高可能是氧化-抗氧化系统与脂蛋白失衡相互作用的结果，检测患者的auAb-oxLDL可能反映体内氧化过程的发生情况。
