固定不动是否与异常脂蛋白谱相关？来自不同队列的观察结果。

Is immobilization associated with an abnormal lipoprotein profile? Observations from a diverse cohort.

作者信息

Bauman W A, Adkins R H, Spungen A M, Herbert R, Schechter C, Smith D, Kemp B J, Gambino R, Maloney P, Waters R L

机构信息

Spinal Cord Damage Research Center, Mount Sinai Medical Center, New York, NY, USA.

出版信息

Spinal Cord. 1999 Jul;37(7):485-93. doi: 10.1038/sj.sc.3100862.

DOI:10.1038/sj.sc.3100862

PMID:10438115

Abstract

OBJECTIVE

The potential effects of ethnicity, gender, and adiposity on the serum lipid profile in persons with spinal cord injury (SCI) were determined.

SUBJECTS

Subjects with SCI were recruited during their annual physical examination from Rancho Los Amigos Medical Center, Downey, California. Sedentary able-bodied controls were Bridge and Tunnel Officers of the Triboro Bridge and Tunnel Authority of the New York City metropolitan area.

METHODS

Serum lipid profiles were investigated in 320 subjects with SCI and compared to those obtained from 303 relatively sedentary able-bodied controls. Serum lipid studies were obtained in the fasting state. Data were collected between 1993 and 1996. All lipid determinations were performed by the same commercial laboratory.

MAIN OUTCOME MEASURES

The dependent variables were the values from the lipid profile analysis. The independent variables consisted of study group, gender, ethnic group, age, duration of injury, and anthropometric measurements.

RESULTS

The serum high-density lipoprotein cholesterol (HDL-c) level was reduced in the SCI compared with the control group (mean+/-SEM) (42+/-0.79 vs 47+/-0.67 mg/dl, P<0.0005). The serum HDL-c level was significantly lower in males with SCI than males in the control group (39+/-0.83 vs 45+/-0.70 mg/dl, P<0.0001), but not for females (51+/-1.54 vs 54 1.52 mg/dl, n.s.). Within the subgroups for whites and Latinos, HDL-c values were also lower in subjects with SCI than in controls (whites: 41+/-1.02 vs 46+/-0.86 mg/dl, P<0.0001; Latinos: 37+/-1.53 vs 42+/-1.59 mg/dl, P<0.05), but not for African Americans (49+/-1.56 vs 51+/-1.27 mg/dl, n.s.). African Americans had higher HDL-c values than whites or Latinos (SCI: 49+/-1.56 vs 41+/-1.02 or 37+/-1.53 mg/dl, P< 0.0001; controls: 51+/-1.27 vs 46+/-0.86 mg/dl, P<0.01 or 42+/-1.59 mg/dl, P<0.0005). In persons with SCI, the serum HDL-c values were inversely related to body mass index and estimated per cent body fat (r=0.27, P<0.0001).

CONCLUSION

In white and Latino males, but not in females or African Americans, immobilization from SCI appears to be associated with lower HDL-c values than in controls.

摘要

目的

确定种族、性别和肥胖对脊髓损伤（SCI）患者血清脂质谱的潜在影响。

受试者

从加利福尼亚州唐尼市的兰乔洛斯阿米戈斯医疗中心的年度体检中招募SCI患者。久坐的健全对照者是纽约市大都市区三区桥梁和隧道管理局的桥梁和隧道官员。

方法

对320名SCI患者的血清脂质谱进行了研究，并与303名相对久坐的健全对照者的脂质谱进行比较。在空腹状态下进行血清脂质研究。数据收集于1993年至1996年之间。所有脂质测定均由同一商业实验室进行。

主要观察指标

因变量为脂质谱分析的值。自变量包括研究组、性别、种族、年龄、损伤持续时间和人体测量指标。

结果

与对照组相比，SCI患者的血清高密度脂蛋白胆固醇（HDL-c）水平降低（均值±标准误）（42±0.79 vs 47±0.67mg/dl，P<0.0005）。SCI男性的血清HDL-c水平显著低于对照组男性（39±0.83 vs 45±0.70mg/dl，P<0.0001），但女性无差异（51±1.54 vs 54±1.52mg/dl，无统计学意义）。在白人和拉丁裔亚组中，SCI患者的HDL-c值也低于对照组（白人：41±1.02 vs 46±0.86mg/dl，P<0.0001；拉丁裔：37±1.53 vs 42±1.59mg/dl，P<0.05），但非裔美国人无差异（49±1.56 vs 51±1.27mg/dl，无统计学意义）。非裔美国人的HDL-c值高于白人和拉丁裔（SCI：49±1.56 vs 41±1.02或37±1.53mg/dl，P<0.0001；对照组：51±1.27 vs 46±0.86mg/dl，P<0.01或42±1.59mg/dl，P<0.0005）。在SCI患者中，血清HDL-c值与体重指数和估计体脂百分比呈负相关（r=0.27，P<0.0001）。