Sunderman F W, Allpass P R, Mitchell J M, Baselt R C, Albert D M
Science. 1979 Feb 9;203(4380):550-3. doi: 10.1126/science.104388.
Exposure of pregnant rats to inhalation of nickel carbonyl on days 7 or 8 of gestation frequently causes the progeny to develop ocular anomalies, including anophthalmia and microphthalmia. The incidence of extraocular anomalies is very low. The specificity of nickel carbonyl for induction of ocular anomalies in rats appears to be unique among known teratogenic agents.
在妊娠第7天或第8天,让怀孕大鼠吸入羰基镍,其后代常常会出现眼部异常,包括无眼和小眼症。眼外异常的发生率非常低。在已知的致畸剂中,羰基镍诱发大鼠眼部异常的特异性似乎是独一无二的。