恒河猴疱疹病毒在体内的B淋巴细胞中建立潜伏感染。
Rhesus rhadinovirus establishes a latent infection in B lymphocytes in vivo.
作者信息
Bergquam E P, Avery N, Shiigi S M, Axthelm M K, Wong S W
机构信息
Division of Pathobiology and Immunology, Oregon Regional Primate Research Center, Beaverton, Oregon 97006, USA.
出版信息
J Virol. 1999 Sep;73(9):7874-6. doi: 10.1128/JVI.73.9.7874-7876.1999.
Abstract
Recent DNA sequence analysis indicates that rhesus rhadinovirus (RRV) is a member of the lymphotropic gamma-2 herpesvirus family. To determine if RRV is lymphotropic, peripheral blood mononuclear cells from naturally infected monkeys were separated by immunomagnetic bead depletion and analyzed for the presence of RRV by virus isolation and nested PCR. The recovery and consistent detection of RRV in the CD20(+)-enriched fraction clearly demonstrates that B lymphocytes are a major site of virus persistence.
摘要
最近的DNA序列分析表明，恒河猴疱疹病毒（RRV）是嗜淋巴细胞性γ-2疱疹病毒家族的成员。为了确定RRV是否具有嗜淋巴细胞性，通过免疫磁珠去除法分离自然感染猴子的外周血单个核细胞，并通过病毒分离和巢式PCR分析RRV的存在情况。在富含CD20(+)的组分中RRV的回收和持续检测清楚地表明B淋巴细胞是病毒持续存在的主要部位。
相似文献
1
Rhesus rhadinovirus establishes a latent infection in B lymphocytes in vivo.恒河猴疱疹病毒在体内的B淋巴细胞中建立潜伏感染。
J Virol. 1999 Sep;73(9):7874-6. doi: 10.1128/JVI.73.9.7874-7876.1999.
2
Infection and persistence of rhesus monkey rhadinovirus in immortalized B-cell lines.恒河猴疱疹病毒在永生化B细胞系中的感染与持续存在。
J Virol. 2006 Apr;80(7):3644-9. doi: 10.1128/JVI.80.7.3644-3649.2006.
3
A herpesvirus of rhesus monkeys related to the human Kaposi's sarcoma-associated herpesvirus.一种与人类卡波西肉瘤相关疱疹病毒有关的恒河猴疱疹病毒。
J Virol. 1997 Dec;71(12):9764-9. doi: 10.1128/JVI.71.12.9764-9769.1997.
4
Experimental infection of rhesus and pig-tailed macaques with macaque rhadinoviruses.用猕猴疱疹病毒对恒河猴和豚尾猕猴进行实验性感染。
J Virol. 1999 Dec;73(12):10320-8. doi: 10.1128/JVI.73.12.10320-10328.1999.
5
Glycoprotein gene sequence variation in rhesus monkey rhadinovirus.恒河猴疱疹病毒糖蛋白基因序列变异。
Virology. 2010 May 10;400(2):175-86. doi: 10.1016/j.virol.2010.01.030. Epub 2010 Feb 20.
6
The rhesus rhadinovirus CD200 homologue affects immune responses and viral loads during in vivo infection.恒河猴疱疹病毒CD200同源物在体内感染期间影响免疫反应和病毒载量。
J Virol. 2014 Sep;88(18):10635-54. doi: 10.1128/JVI.01276-14. Epub 2014 Jul 2.
7
8
A Recombinant Rhesus Monkey Rhadinovirus Deleted of Glycoprotein L Establishes Persistent Infection of Rhesus Macaques and Elicits Conventional T Cell Responses.一种缺失糖蛋白 L 的重组恒河猴疱疹病毒可建立恒河猴的持续性感染并引发常规 T 细胞应答。
J Virol. 2020 Jan 6;94(2). doi: 10.1128/JVI.01093-19.
9
A genetic system for rhesus monkey rhadinovirus: use of recombinant virus to quantitate antibody-mediated neutralization.恒河猴疱疹病毒的遗传系统：利用重组病毒定量抗体介导的中和作用。
J Virol. 2006 Feb;80(3):1549-62. doi: 10.1128/JVI.80.3.1549-1562.2006.
10
Rhesus rhadinovirus infection in healthy and SIV-infected macaques at Tulane National Primate Research Center.杜兰国家灵长类动物研究中心健康和感染猴免疫缺陷病毒的猕猴中的恒河猴疱疹病毒感染
J Med Primatol. 2003 Feb;32(1):1-6. doi: 10.1034/j.1600-0684.2003.00007.x.
引用本文的文献
1
Generation of chimeric forms of rhesus macaque rhadinovirus expressing KSHV envelope glycoproteins gH and gL for utilization in an NHP model of infection.构建表达卡波西肉瘤相关疱疹病毒包膜糖蛋白gH和gL的恒河猴疱疹病毒嵌合形式，用于非人灵长类动物感染模型。
J Virol. 2025 Feb 25;99(2):e0192324. doi: 10.1128/jvi.01923-24. Epub 2025 Jan 21.
2
Guinea pig herpes like virus is a gamma herpesvirus.豚鼠疱疹样病毒是一种γ疱疹病毒。
Virus Genes. 2024 Apr;60(2):148-158. doi: 10.1007/s11262-024-02054-x. Epub 2024 Feb 10.
3
Membrane-associated and secreted forms of the Rhesus macaque rhadinovirus-encoded CD200 homologue and cellular CD200 demonstrate differential effects on Rhesus Macaque CD200 Receptor signaling and regulation of myeloid cell activation.恒河猴疱疹病毒编码的CD200同源物的膜相关和分泌形式以及细胞CD200对恒河猴CD200受体信号传导和髓样细胞活化调节具有不同影响。
J Virol. 2021 Mar 1;95(5). doi: 10.1128/JVI.01654-20. Epub 2020 Dec 16.
4
Molecular analysis of lymphoid tissue from rhesus macaque rhadinovirus-infected monkeys identifies alterations in host genes associated with oncogenesis.从感染恒河猴疱疹病毒的猕猴的淋巴组织进行分子分析，鉴定出与致癌相关的宿主基因的改变。
PLoS One. 2020 Feb 4;15(2):e0228484. doi: 10.1371/journal.pone.0228484. eCollection 2020.
5
Kaposi's Sarcoma-Associated Herpesvirus Latency Locus Renders B Cells Hyperresponsive to Secondary Infections.卡波西肉瘤相关疱疹病毒潜伏部位使 B 细胞对二次感染高度敏感。
J Virol. 2018 Sep 12;92(19). doi: 10.1128/JVI.01138-18. Print 2018 Oct 1.
6
Macaque homologs of Kaposi's sarcoma-associated herpesvirus (KSHV) infect germinal center lymphoid cells, epithelial cells in skin and gastrointestinal tract and gonadal germ cells in naturally infected macaques.猿猴疱疹病毒（KSHV）的猴同源物感染生发中心淋巴细胞、皮肤和胃肠道上皮细胞以及自然感染的猕猴的生殖细胞。
Virology. 2018 Jun;519:106-120. doi: 10.1016/j.virol.2018.04.007. Epub 2018 Apr 22.
7
Use of a gamma-2 herpesvirus as a vector to deliver antibodies to rhesus monkeys.使用γ-2型疱疹病毒作为载体向恒河猴递送抗体。
Gene Ther. 2017 Aug;24(8):487-492. doi: 10.1038/gt.2017.49. Epub 2017 Jun 29.
8
The rhesus rhadinovirus CD200 homologue affects immune responses and viral loads during in vivo infection.恒河猴疱疹病毒CD200同源物在体内感染期间影响免疫反应和病毒载量。
J Virol. 2014 Sep;88(18):10635-54. doi: 10.1128/JVI.01276-14. Epub 2014 Jul 2.
9
Rhesus macaque rhadinovirus-associated disease.恒河猴疱疹病毒相关性疾病。
Curr Opin Virol. 2013 Jun;3(3):245-50. doi: 10.1016/j.coviro.2013.05.016. Epub 2013 Jun 6.
10
Rhesus monkey rhadinovirus uses eph family receptors for entry into B cells and endothelial cells but not fibroblasts.恒河猴疱疹病毒利用 Eph 家族受体进入 B 细胞和内皮细胞，但不进入成纤维细胞。
PLoS Pathog. 2013;9(5):e1003360. doi: 10.1371/journal.ppat.1003360. Epub 2013 May 16.
本文引用的文献
1
Induction of B cell hyperplasia in simian immunodeficiency virus-infected rhesus macaques with the simian homologue of Kaposi's sarcoma-associated herpesvirus.用卡波西肉瘤相关疱疹病毒的猿猴同源物在感染猿猴免疫缺陷病毒的恒河猴中诱导B细胞增生。
J Exp Med. 1999 Sep 20;190(6):827-40. doi: 10.1084/jem.190.6.827.
2
Sequence and genomic analysis of a Rhesus macaque rhadinovirus with similarity to Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8.与卡波西肉瘤相关疱疹病毒/人类疱疹病毒8具有相似性的恒河猴rhadinovirus的序列和基因组分析
J Virol. 1999 Apr;73(4):3040-53. doi: 10.1128/JVI.73.4.3040-3053.1999.
3
Characterization of rhesus cytomegalovirus genes associated with anti-viral susceptibility.与抗病毒易感性相关的恒河猴巨细胞病毒基因的特征分析
Virology. 1998 Jan 20;240(2):338-48. doi: 10.1006/viro.1997.8935.
4
A herpesvirus of rhesus monkeys related to the human Kaposi's sarcoma-associated herpesvirus.一种与人类卡波西肉瘤相关疱疹病毒有关的恒河猴疱疹病毒。
J Virol. 1997 Dec;71(12):9764-9. doi: 10.1128/JVI.71.12.9764-9769.1997.
5
Monocytes in Kaposi's sarcoma lesions are productively infected by human herpesvirus 8.卡波西肉瘤病变中的单核细胞被人类疱疹病毒8型有效感染。
J Virol. 1997 Oct;71(10):7963-8. doi: 10.1128/JVI.71.10.7963-7968.1997.
6
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma.在艾滋病相关的卡波西肉瘤中鉴定出疱疹病毒样DNA序列。
Science. 1994 Dec 16;266(5192):1865-9. doi: 10.1126/science.7997879.
7
Herpes-like sequences in HIV-infected and uninfected Kaposi's sarcoma patients.感染和未感染人类免疫缺陷病毒的卡波西肉瘤患者中的疱疹样序列
Science. 1995 Apr 28;268(5210):582-3. doi: 10.1126/science.7725108.
8
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas.艾滋病相关体腔淋巴瘤中卡波西肉瘤相关疱疹病毒样DNA序列
N Engl J Med. 1995 May 4;332(18):1186-91. doi: 10.1056/NEJM199505043321802.
9
Detection of Kaposi sarcoma associated herpesvirus in peripheral blood of HIV-infected individuals and progression to Kaposi's sarcoma.在HIV感染个体外周血中检测卡波西肉瘤相关疱疹病毒及向卡波西肉瘤的进展。
Lancet. 1995 Sep 23;346(8978):799-802. doi: 10.1016/s0140-6736(95)91619-9.
10
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease.多中心性Castleman病中卡波西肉瘤相关疱疹病毒样DNA序列
Blood. 1995 Aug 15;86(4):1276-80.
Zotero 插件