恒河猴疱疹病毒糖蛋白基因序列变异。
Glycoprotein gene sequence variation in rhesus monkey rhadinovirus.
机构信息
New England Primate Research Center, Harvard Medical School, Southborough, MA 01772-9102, USA.
出版信息
Virology. 2010 May 10;400(2):175-86. doi: 10.1016/j.virol.2010.01.030. Epub 2010 Feb 20.
Abstract
Gene sequences for seven glycoproteins from 20 independent isolates of rhesus monkey rhadinovirus (RRV) and of the corresponding seven glycoprotein genes from nine strains of the Kaposi's sarcoma-associated herpesvirus (KSHV) were obtained and analyzed. Phylogenetic analysis revealed two discrete groupings of RRV gH sequences, two discrete groupings of RRV gL sequences and two discrete groupings of RRV gB sequences. We called these phylogenetic groupings gH(a), gH(b), gL(a), gL(b), gB(a) and gB(b). gH(a) was always paired with gL(a) and gH(b) was always paired with gL(b) for any individual RRV isolate. Since gH and gL are known to be interacting partners, these results suggest the need of matching sequence types for function of these cooperating proteins. gB phylogenetic grouping was not associated with gH/gL phylogenetic grouping. Our results demonstrate two distinct, distantly-related phylogenetic groupings of gH and gL of RRV despite a remarkable degree of sequence conservation within each individual phylogenetic group.
摘要
从 20 个独立分离株的恒河猴疱疹病毒（RRV）中获得了 7 种糖蛋白的基因序列和 9 株卡波西肉瘤相关疱疹病毒（KSHV）的相应 7 种糖蛋白基因，并对其进行了分析。系统发育分析显示，RRV gH 序列存在两个离散的分组，RRV gL 序列存在两个离散的分组，RRV gB 序列也存在两个离散的分组。我们将这些系统发育分组称为 gH(a)、gH(b)、gL(a)、gL(b)、gB(a)和 gB(b)。对于任何一个 RRV 分离株，gH(a)总是与 gL(a)配对，gH(b)总是与 gL(b)配对。由于 gH 和 gL 已知是相互作用的伙伴，这些结果表明这些协同蛋白的功能需要匹配序列类型。gB 系统发育分组与 gH/gL 系统发育分组无关。尽管每个单独的系统发育分组内存在显著的序列保守性，但我们的结果表明 RRV 的 gH 和 gL 存在两个截然不同的、远缘相关的系统发育分组。
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