Santibanez S, Heider A, Gerike E, Agafonov A, Schreier E
Robert Koch Institute, Berlin, Germany.
J Med Virol. 1999 Jul;58(3):313-20.
Sequence analysis of 285 nucleotides located on the variable part of the N gene was undertaken on measles virus (MV) samples collected from acutely infected patients in Germany, the Czech Republic, Denmark, Poland, and Russia. Two distinct genotypes (C2 and D6) have circulated in Germany between 1993 and 1996. Isolates of genotype C2 were related to strains reported in Germany before 1993. This genotype was also found in the Czech Republic in 1992 and in Denmark in 1997. The occurrence of genotype D6 in Germany is described below for the first time. In 1998, this genotype was identified in Poland. Genotypes C2 and D6 were also reported in Spain and in the United Kingdom between 1992 and 1996. Therefore, it is concluded that these genotypes are widely distributed over Europe. The analysis of the isolates from Russia revealed that genotype A was present in 1988 in the European part of the country and in 1996 in Siberia. An isolate identified in 1997 in Siberia belonged to genotype D6, which had never been found previously in Russia. We also analysed MV obtained from a case of subacute sclerosing panencephalitis (SSPE) in 1995 in Turkey. A comparison of this sequence with published sequences implied that this SSPE case was associated with a new genetic lineage of MV.
对从德国、捷克共和国、丹麦、波兰和俄罗斯的急性感染患者身上采集的麻疹病毒（MV）样本，进行了N基因可变区285个核苷酸的序列分析。1993年至1996年间，两种不同的基因型（C2和D6）在德国传播。C2基因型的分离株与1993年以前德国报告的毒株有关。1992年在捷克共和国以及1997年在丹麦也发现了这种基因型。下文首次描述了D6基因型在德国的出现情况。1998年，在波兰鉴定出了这种基因型。1992年至1996年间，西班牙和英国也报告了C2和D6基因型。因此，可以得出结论，这些基因型在欧洲广泛分布。对来自俄罗斯的分离株的分析表明，1988年在该国欧洲部分以及1996年在西伯利亚存在A基因型。1997年在西伯利亚鉴定出的一株分离株属于D6基因型，此前在俄罗斯从未发现过这种基因型。我们还分析了1995年从土耳其一例亚急性硬化性全脑炎（SSPE）病例中获得的麻疹病毒。将该序列与已发表的序列进行比较表明，这例SSPE病例与一种新的麻疹病毒基因谱系有关。
