Rosell M, Regnström J, Kallner A, Hellénius M L
Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Department of Emergency and Cardiovascular Medicine, King Gustav V Research Institute, Karolinska Institute, Stockholm, Sweden.
J Intern Med. 1999 Aug;246(2):219-26. doi: 10.1046/j.1365-2796.1999.00522.x.
To study whether advice on diet and/or exercise, given in order to reduce cardiovascular risk factors in middle-aged men, affects the intake of antioxidants, urate concentration and the total antioxidant capacity in serum.
A 6-month randomized controlled intervention study.
Primary Health Care in Sollentuna, Stockholm, and the Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
One hundred and fifty-eight healthy men (46.2 +/- 5.0 years) with moderately raised cardiovascular risk factors.
Advice on diet (D, n = 40), exercise (E, n = 39), diet and exercise (DE, n = 39) and a control group (C, n = 39).
Dietary intake, exercise habits, S-urate and the antioxidant capacity in serum (TAOC).
After 6 months, changes in dietary and exercise habits were seen in all three intervention groups and favourable effects were seen on BMI, waist circumference, blood pressure, S-cholesterol and fasting insulin. The intake of alpha-tocopherol was decreased in groups D and E (P < 0.01) and beta-carotene was increased in groups D and DE (P < 0.01). In group DE, the intake of vitamin C was increased (P < 0.05). S-urate was reduced in group D from 345 to 325 micromol L-1 (P < 0.05). No significant changes in TAOC were seen in any group. S-urate and TAOC were correlated (r = 0. 58, P < 0.001) and S-urate was correlated to several parameters in the metabolic syndrome.
Favourable changes in diet and exercise reduced several cardiovascular risk factors but did not affect the total antioxidant capacity in serum. S-urate was a strong determinant of the antioxidant capacity.
研究为降低中年男性心血管危险因素而提供的饮食和/或运动建议是否会影响抗氧化剂的摄入量、尿酸浓度和血清总抗氧化能力。
一项为期6个月的随机对照干预研究。
瑞典斯德哥尔摩索伦特纳的初级卫生保健机构以及斯德哥尔摩卡罗林斯卡医院内科。
158名心血管危险因素中度升高的健康男性（46.2±5.0岁）。
饮食建议组（D组，n = 40）、运动建议组（E组，n = 39）、饮食和运动建议组（DE组，n = 39）以及对照组（C组，n = 39）。
饮食摄入量、运动习惯、血清尿酸（S-urate）和血清抗氧化能力（TAOC）。
6个月后，所有三个干预组的饮食和运动习惯均有改变，且对体重指数、腰围、血压、血清胆固醇和空腹胰岛素产生了有益影响。D组和E组的α-生育酚摄入量降低（P < 0.01），D组和DE组的β-胡萝卜素摄入量增加（P < 0.01）。DE组的维生素C摄入量增加（P < 0.05）。D组的血清尿酸从345微摩尔/升降至325微摩尔/升（P < 0.05）。各组的TAOC均无显著变化。血清尿酸与TAOC相关（r = 0.58，P < 0.001），血清尿酸与代谢综合征的几个参数相关。
饮食和运动的有益改变降低了多种心血管危险因素，但未影响血清总抗氧化能力。血清尿酸是抗氧化能力的一个重要决定因素。
