Barrett M P, Walmsley A R, Gould G W
Divisions of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
Curr Opin Cell Biol. 1999 Aug;11(4):496-502. doi: 10.1016/s0955-0674(99)80072-6.
Sugar transporters from one group of the major facilitator superfamily of membrane transporters. A conserved common central pore structure lies at the heart of these transporters and diverse functionality is brought about by alterations to this pore or regions associated with it. Recent mutagenesis studies of sugar transporters within the framework of tenable models for the distantly related lactose permease argue that this model is a good paradigm for other members of the major facilitator superfamily.
糖转运蛋白属于膜转运蛋白主要易化子超家族中的一类。这些转运蛋白的核心是一个保守的共同中央孔结构，通过对该孔或与其相关区域的改变实现了多样的功能。近期在与乳糖通透酶远亲的合理模型框架内对糖转运蛋白进行的诱变研究表明，该模型是主要易化子超家族其他成员的良好范例。
