Freie Universitaet Berlin, Institute of Pharmacy-Pharmaceutical Biology, Koenigin-Luise-Str. 2+4, D-14195 Berlin, Germany.
Molecules. 2018 Oct 6;23(10):2544. doi: 10.3390/molecules23102544.
The intestinal absorption of fatty acids, glucose and fructose is part of the basic requirements for the provision of energy in the body. High access of saturated longchain fatty acids (LCFA), glucose and fructose can facilitate the development of metabolic diseases, particularly the metabolic syndrome and type-2 diabetes mellitus (T2DM). Research has been done to find substances which decelerate or inhibit intestinal resorption of these specific food components. Promising targets are the inhibition of intestinal long-chain fatty acid (FATP2, FATP4), glucose (SGLT1, GLUT2) and fructose (GLUT2, GLUT5) transporters by plant extracts and by pure substances. The largest part of active components in plant extracts belongs to the group of polyphenols. This review summarizes the knowledge about binding sites of named transporters and lists the plant extracts which were tested in Caco-2 cells regarding uptake inhibition.
脂肪酸、葡萄糖和果糖的肠道吸收是为身体提供能量的基本要求的一部分。大量摄入饱和长链脂肪酸（LCFA）、葡萄糖和果糖会促进代谢疾病的发展，特别是代谢综合征和 2 型糖尿病（T2DM）。已经进行了研究以寻找可以减缓或抑制这些特定食物成分肠道吸收的物质。有前途的靶点是通过植物提取物和纯物质抑制肠道长链脂肪酸（FATP2、FATP4）、葡萄糖（SGLT1、GLUT2）和果糖（GLUT2、GLUT5）转运蛋白。植物提取物中最大的活性成分部分属于多酚类。这篇综述总结了有关命名转运体结合位点的知识，并列出了在 Caco-2 细胞中针对摄取抑制进行测试的植物提取物。
