采用微量稀释肉汤法评估单宁及相关化合物的抗菌效力。

Evaluation of the antimicrobial potency of tannins and related compounds using the microdilution broth method.

作者信息

Kolodzeij H, Kayser O, Latté K P, Ferreira D

出版信息

Planta Med. 1999 Jun;65(5):444-6. doi: 10.1055/s-2006-960806.

DOI:10.1055/s-2006-960806

Abstract

The antimicrobial activity of a total of 27 tannins and related compounds was evaluated against 8 microorganisms, including 2 Gram-positive (Bacillus subtilis, Staphylococcus aureus), 4 Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis), and 2 yeasts (Candida albicans, Cryptococcus neoformans). The compounds tested were generally found to possess only weak to moderate antibacterial, but fairly high anticryptococcal activities. Attention is given to structure-activity relationships with emphasis on simple galloyl esters, hydrolyzable tannins and proanthcyanidins among this class of secondary products.

摘要

对总共27种单宁及相关化合物针对8种微生物的抗菌活性进行了评估，这些微生物包括2种革兰氏阳性菌（枯草芽孢杆菌、金黄色葡萄球菌）、4种革兰氏阴性菌（大肠杆菌、肺炎克雷伯菌、铜绿假单胞菌、奇异变形杆菌）以及2种酵母菌（白色念珠菌、新型隐球菌）。一般发现所测试的化合物仅具有弱至中等的抗菌活性，但抗隐球菌活性相当高。重点关注了这类次生产物中简单没食子酸酯、可水解单宁和原花青素之间的构效关系。