采用卢里氏肺结节计数法评估结核分枝杆菌CDC1551和H37Rv对家兔的毒力。
Virulence of Mycobacterium tuberculosis CDC1551 and H37Rv in rabbits evaluated by Lurie's pulmonary tubercle count method.
作者信息
Bishai W R, Dannenberg A M, Parrish N, Ruiz R, Chen P, Zook B C, Johnson W, Boles J W, Pitt M L
机构信息
Department of Molecular Microbiology and Immunology, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland, USA.
出版信息
Infect Immun. 1999 Sep;67(9):4931-4. doi: 10.1128/IAI.67.9.4931-4934.1999.
Abstract
The virulence of the CDC1551 strain of Mycobacterium tuberculosis was compared to that of H37Rv in a rabbit inhalation model. While rabbits that inhaled the two strains produced equal numbers of grossly visible primary tubercles, CDC1551 tubercles were smaller and contained fewer bacilli than H37Rv tubercles. These findings suggest that a miniepidemic near the Kentucky-Tennessee border caused by CDC1551 was due not to increased virulence but to increased transmissibility.
摘要
在兔吸入模型中，对结核分枝杆菌CDC1551菌株与H37Rv菌株的毒力进行了比较。吸入这两种菌株的兔子产生的肉眼可见的原发性结核结节数量相同，但CDC1551结核结节比H37Rv结核结节更小，且所含杆菌更少。这些发现表明，肯塔基州和田纳西州边境附近由CDC1551引起的小规模流行不是由于毒力增加，而是由于传播性增强。
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