结核分枝杆菌CDC1551在体外对活性氮和氧中间体具有抗性。
Mycobacterium tuberculosis CDC1551 is resistant to reactive nitrogen and oxygen intermediates in vitro.
作者信息
Firmani Marcia A, Riley Lee W
机构信息
School of Public Health, Division of Infectious Disease, University of California at Berkeley, Berkeley, California 94720, USA.
出版信息
Infect Immun. 2002 Jul;70(7):3965-8. doi: 10.1128/IAI.70.7.3965-3968.2002.
Abstract
Resistance to reactive oxygen intermediates and reactive nitrogen intermediates in vitro of a clinical isolate of Mycobacterium tuberculosis (CDC1551) that caused a large outbreak of tuberculosis was compared to that of M. tuberculosis strains CB3.3, H37Rv, H37Ra, Erdman, RJ2E, C.C. 13, and C.C. 22 as well as M. bovis strains Ravenel and BCG. CDC1551 and CB3.3 were significantly more resistant to both hydrogen peroxide (H(2)O(2)) and acidified sodium nitrite than were the other strains tested. This biological phenotype may serve as an in vitro marker for clinical strains of M. tuberculosis likely to cause a large outbreak of tuberculosis.
摘要
将引起大规模结核病暴发的结核分枝杆菌临床分离株（CDC1551）在体外对活性氧中间体和活性氮中间体的抗性，与结核分枝杆菌菌株CB3.3、H37Rv、H37Ra、Erdman、RJ2E、CC13和CC22以及牛分枝杆菌菌株Ravenel和卡介苗进行了比较。与其他受试菌株相比，CDC1551和CB3.3对过氧化氢（H₂O₂）和酸化亚硝酸钠均具有显著更高的抗性。这种生物学表型可能作为可能引起大规模结核病暴发的结核分枝杆菌临床菌株的体外标志物。
相似文献
1
Mycobacterium tuberculosis CDC1551 is resistant to reactive nitrogen and oxygen intermediates in vitro.结核分枝杆菌CDC1551在体外对活性氮和氧中间体具有抗性。
Infect Immun. 2002 Jul;70(7):3965-8. doi: 10.1128/IAI.70.7.3965-3968.2002.
2
Reactive nitrogen intermediates have a bacteriostatic effect on Mycobacterium tuberculosis in vitro.活性氮中间体在体外对结核分枝杆菌具有抑菌作用。
J Clin Microbiol. 2002 Sep;40(9):3162-6. doi: 10.1128/JCM.40.9.3162-3166.2002.
3
Low concentrations of nitric oxide exert a hormetic effect on Mycobacterium tuberculosis in vitro.低浓度一氧化氮在体外对结核分枝杆菌发挥一种应激效应。
J Clin Microbiol. 2005 Sep;43(9):4844-6. doi: 10.1128/JCM.43.9.4844-4846.2005.
4
5
Reduced susceptibility of clinical strains of Mycobacterium tuberculosis to reactive nitrogen species promotes survival in activated macrophages.结核分枝杆菌临床菌株对活性氮物质的敏感性降低促进其在活化巨噬细胞中的存活。
PLoS One. 2017 Jul 13;12(7):e0181221. doi: 10.1371/journal.pone.0181221. eCollection 2017.
6
Virulence of Mycobacterium tuberculosis CDC1551 and H37Rv in rabbits evaluated by Lurie's pulmonary tubercle count method.采用卢里氏肺结节计数法评估结核分枝杆菌CDC1551和H37Rv对家兔的毒力。
Infect Immun. 1999 Sep;67(9):4931-4. doi: 10.1128/IAI.67.9.4931-4934.1999.
7
Rifampicin resistance in tuberculosis outbreak, London, England.英国伦敦结核病暴发中的利福平耐药情况。
Emerg Infect Dis. 2005 Jun;11(6):931-4. doi: 10.3201/eid1106.041262.
8
Multiplex PCR assay to aid in the identification of the highly transmissible Mycobacterium tuberculosis strain CDC1551.多重聚合酶链反应检测法有助于鉴定高传播性结核分枝杆菌菌株CDC1551。
Tuber Lung Dis. 1999;79(5):273-8. doi: 10.1054/tuld.1999.0197.
9
Extrapulmonary dissemination of Mycobacterium bovis but not Mycobacterium tuberculosis in a bronchoscopic rabbit model of cavitary tuberculosis.在空洞型肺结核的支气管镜检查兔模型中，牛分枝杆菌而非结核分枝杆菌的肺外播散情况。
Infect Immun. 2009 Feb;77(2):598-603. doi: 10.1128/IAI.01132-08. Epub 2008 Dec 8.
10
Molecular markers demonstrate that the first described multidrug-resistant Mycobacterium bovis outbreak was due to Mycobacterium tuberculosis.分子标记表明，首次描述的多重耐药牛分枝杆菌疫情是由结核分枝杆菌引起的。
J Clin Microbiol. 1999 Apr;37(4):971-5. doi: 10.1128/JCM.37.4.971-975.1999.
引用本文的文献
1
Novel gene similar to nitrite reductase (NO forming) plays potentially important role in the latency of tuberculosis.新型基因类似于亚硝酸盐还原酶（形成 NO），在结核病潜伏期发挥重要作用。
Sci Rep. 2021 Oct 6;11(1):19813. doi: 10.1038/s41598-021-99346-1.
2
Immunomodulatory Agents Combat Multidrug-Resistant Tuberculosis by Improving Antimicrobial Immunity.免疫调节剂通过增强抗菌免疫来对抗耐多药结核病。
J Infect Dis. 2021 Jul 15;224(2):332-344. doi: 10.1093/infdis/jiab100.
3
Host-Directed Therapy as a Novel Treatment Strategy to Overcome Tuberculosis: Targeting Immune Modulation.宿主导向疗法作为一种克服结核病的新型治疗策略：靶向免疫调节
Antibiotics (Basel). 2020 Jan 7;9(1):21. doi: 10.3390/antibiotics9010021.
4
Role of Oxidative Stress in the Pathology and Management of Human Tuberculosis.氧化应激在人类结核病的病理和治疗中的作用。
Oxid Med Cell Longev. 2018 Oct 11;2018:7695364. doi: 10.1155/2018/7695364. eCollection 2018.
5
Intercepting signalling mechanism to control environmental biofouling.拦截信号传导机制以控制环境生物污垢。
3 Biotech. 2018 Aug;8(8):364. doi: 10.1007/s13205-018-1383-z. Epub 2018 Aug 9.
6
Nitric Oxide in the Pathogenesis and Treatment of Tuberculosis.一氧化氮在结核病发病机制及治疗中的作用
Front Microbiol. 2017 Oct 12;8:2008. doi: 10.3389/fmicb.2017.02008. eCollection 2017.
7
Reduced susceptibility of clinical strains of Mycobacterium tuberculosis to reactive nitrogen species promotes survival in activated macrophages.结核分枝杆菌临床菌株对活性氮物质的敏感性降低促进其在活化巨噬细胞中的存活。
PLoS One. 2017 Jul 13;12(7):e0181221. doi: 10.1371/journal.pone.0181221. eCollection 2017.
8
Resistance to first-line anti-TB drugs is associated with reduced nitric oxide susceptibility in Mycobacterium tuberculosis.结核分枝杆菌对一线抗结核药物的耐药性与其对一氧化氮的敏感性降低有关。
PLoS One. 2012;7(6):e39891. doi: 10.1371/journal.pone.0039891. Epub 2012 Jun 29.
9
Does M. tuberculosis genomic diversity explain disease diversity?结核分枝杆菌的基因组多样性能解释疾病多样性吗？
Drug Discov Today Dis Mech. 2010 Spring;7(1):e43-e59. doi: 10.1016/j.ddmec.2010.09.004.
10
Functional genetic diversity among Mycobacterium tuberculosis complex clinical isolates: delineation of conserved core and lineage-specific transcriptomes during intracellular survival.结核分枝杆菌复合体临床分离株的功能遗传多样性：在细胞内生存过程中保守核心和谱系特异性转录组的描绘。
PLoS Pathog. 2010 Jul 8;6(7):e1000988. doi: 10.1371/journal.ppat.1000988.
本文引用的文献
1
Induction of direct antimicrobial activity through mammalian toll-like receptors.通过哺乳动物Toll样受体诱导直接抗菌活性。
Science. 2001 Feb 23;291(5508):1544-7. doi: 10.1126/science.291.5508.1544.
2
Lethal Mycobacterium bovis Bacillus Calmette Guérin infection in nitric oxide synthase 2-deficient mice: cell-mediated immunity requires nitric oxide synthase 2.一氧化氮合酶2缺陷小鼠中的致死性牛分枝杆菌卡介苗感染：细胞介导的免疫需要一氧化氮合酶2 。
Lab Invest. 2000 Sep;80(9):1385-97. doi: 10.1038/labinvest.3780146.
3
RFLP patterns and risk factors for recent tuberculosis transmission among hospitalized tuberculosis patients in Rio de Janeiro, Brazil.
Trans R Soc Trop Med Hyg. 2000 May-Jun;94(3):271-5. doi: 10.1016/s0035-9203(00)90317-1.
4
Virulence of recent notorious Mycobacterium tuberculosis isolates.近期臭名昭著的结核分枝杆菌分离株的毒力。
Tuber Lung Dis. 1999;79(6):379-81. doi: 10.1054/tuld.1999.0221.
5
Growth of a highly virulent strain of Mycobacterium tuberculosis in mice of differing susceptibility to tuberculous challenge.结核分枝杆菌高毒力菌株在对结核感染易感性不同的小鼠体内的生长情况。
Tuber Lung Dis. 1999;79(6):367-70. doi: 10.1054/tuld.1999.0214.
6
Toxicity of nitrogen oxides and related oxidants on mycobacteria: M. tuberculosis is resistant to peroxynitrite anion.氮氧化物及相关氧化剂对分枝杆菌的毒性：结核分枝杆菌对过氧亚硝酸根阴离子具有抗性。
Tuber Lung Dis. 1999;79(4):191-8. doi: 10.1054/tuld.1998.0203.
7
Growth rate of mycobacteria in mice as an unreliable indicator of mycobacterial virulence.小鼠体内分枝杆菌的生长速率作为分枝杆菌毒力的不可靠指标。
Infect Immun. 1999 Oct;67(10):5483-5. doi: 10.1128/IAI.67.10.5483-5485.1999.
8
Virulence of Mycobacterium tuberculosis CDC1551 and H37Rv in rabbits evaluated by Lurie's pulmonary tubercle count method.采用卢里氏肺结节计数法评估结核分枝杆菌CDC1551和H37Rv对家兔的毒力。
Infect Immun. 1999 Sep;67(9):4931-4. doi: 10.1128/IAI.67.9.4931-4934.1999.
9
noxR3, a novel gene from Mycobacterium tuberculosis, protects Salmonella typhimurium from nitrosative and oxidative stress.noxR3是一种来自结核分枝杆菌的新基因，可保护鼠伤寒沙门氏菌免受亚硝化应激和氧化应激。
Infect Immun. 1999 Jul;67(7):3276-83. doi: 10.1128/IAI.67.7.3276-3283.1999.
Zotero 插件