Daculsi G, Weiss P, Bouler J M, Gauthier O, Millot F, Aguado E
Centre de Recherche sur les Matériaux d'Intérêt Biologique INSERM, E99-03, Faculté de Chirurgie Dentaire, Nantes, France.
Bone. 1999 Aug;25(2 Suppl):59S-61S. doi: 10.1016/s8756-3282(99)00135-0.
Calcium phosphate materials have been increasingly employed in orthopedic and dental applications in recent years and are now being developed for use in noninvasive surgery or as carriers for drug delivery systems. We developed an injectable bone substitute (IBS) constituted of biphasic calcium phosphate and a hydrosoluble polymer as a carrier. In vivo biocompatibility and biofunctionality of IBS were tested in rabbits using implants in osseous and nonosseous areas. The results obtained demonstrated that the concept of IBS, a filler without initial mechanical properties but able to be rapidly resorbed and replaced by newly formed bone, can be applied to new surgical applications in orthopedic surgery, maxillofacial surgery, and dentistry for pulp capping and root filling.
近年来，磷酸钙材料在骨科和牙科应用中越来越多地被使用，目前正在开发用于无创手术或作为药物递送系统的载体。我们开发了一种由双相磷酸钙和水溶性聚合物作为载体组成的可注射骨替代物（IBS）。使用骨内和非骨区域的植入物在兔子身上测试了IBS的体内生物相容性和生物功能。获得的结果表明，IBS的概念，即一种没有初始机械性能但能够迅速被吸收并被新形成的骨替代的填充剂，可应用于骨科手术、颌面外科和牙科的牙髓盖髓术和根管充填等新的外科应用中。
