延长脾内胰岛异种移植的存活时间。

Prolongation of intrasplenic islet xenograft survival.

作者信息

Janney C G, Lacy P E, Finke E H, Davie J M

出版信息

Am J Pathol. 1982 Apr;107(1):1-5.

PMID:6801990

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1915984/

Abstract

The spleen has been examined as a possible site for transplantation of rat islets into diabetic mice. Marked prolongation of islet xenograft survival in the spleen can be achieved with in vitro culture (24 C) and a single injection of either rabbit antiserum to mouse lymphocytes (MALS) alone or MALS and rabbit antiserum to rat lymphocytes (RALS) into the recipients. The percentage of survival of intrasplenic xenografts at 100 days was 16%, as compared with 70% when rat islet xenografts were transplanted via the portal vein. Further improvement in pretreatment regimens will be needed before the spleen can be used as an effective site for possible future islet allograft or xenograft transplants in man.

摘要

脾脏已被作为将大鼠胰岛移植到糖尿病小鼠体内的一个可能部位进行了研究。通过体外培养（24℃）以及向受体单独单次注射兔抗小鼠淋巴细胞抗血清（MALS）或MALS与兔抗大鼠淋巴细胞抗血清（RALS），可使脾脏中胰岛异种移植物的存活时间显著延长。脾内异种移植物在100天时的存活百分比为16%，而大鼠胰岛异种移植物经门静脉移植时的存活百分比为70%。在脾脏能够作为人类未来可能进行胰岛同种异体移植或异种移植的有效部位之前，还需要进一步改进预处理方案。