Leahy M J, de Mul F F, Nilsson G E, Maniewski R
University of Oxford, Faculty of Physics, Department of Engineering Science, England.
Technol Health Care. 1999;7(2-3):143-62.
This paper reviews the development and use of laser-Doppler perfusion monitors and imagers over the past two decades. The enormous interest in microvascular blood perfusion coupled with the 'ease of use' of the technique has led to 1500+ publications citing its use. However, useful results can only be achieved with an understanding of the basic principles of the instrumentation and its application in the various clinical disciplines. The basic theoretical background is explored and definitions of blood perfusion and laser-Doppler perfusion are established. The calibration method is then described together with potential routes to standardisation. A guide to the limitations in application of the technique gives the user a clear indication of what can be achieved in new studies as well as possible inadequacy in some published investigations.
本文回顾了过去二十年来激光多普勒灌注监测仪和成像仪的发展与应用。对微血管血液灌注的极大兴趣以及该技术的“易用性”，使得超过1500篇出版物引用了其应用。然而，只有在理解仪器的基本原理及其在各个临床学科中的应用的情况下，才能获得有用的结果。本文探讨了基本理论背景，并确立了血液灌注和激光多普勒灌注的定义。接着描述了校准方法以及潜在的标准化途径。该技术应用局限性指南为用户清晰地指明了在新研究中能够实现的目标，以及一些已发表研究中可能存在的不足之处。
