Guo Y L, Yu M L, Hsu C C, Rogan W J
National Cheng Kung University Medical College, Tainan, Taiwan.
Environ Health Perspect. 1999 Sep;107(9):715-9. doi: 10.1289/ehp.99107715.
In 1979, a mass poisoning involving 2,000 people occurred in central Taiwan from ingestion of cooking oil contaminated by polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs). We studied the prevalence of medical conditions in the exposed individuals and in a neighborhood control group. Starting with a registry of the exposed individuals from 1983, we updated the addresses of exposed individuals and identified a control group matched for age, sex, and neighborhood in 1979. In 1993, individuals 30 years of age or older were interviewed by telephone. We obtained usable information from 795 exposed subjects and 693 control subjects. Lifetime prevalence of chloracne, abnormal nails, hyperkeratosis, skin allergy, goiter, headache, gum pigmentation, and broken teeth were observed more frequently in the PCB/PCDF-exposed men and women. The exposed women reported anemia 2. 3 times more frequently than controls. The exposed men reported arthritis and herniated intervertebral disks 4.1 and 2.9 times, respectively, more frequently than controls. There was no difference in reported prevalences of other medical conditions. We conclude that Taiwanese people exposed to high levels of PCBs and PCDFs reported more frequent medical problems, including skin diseases, goiter, anemia, and joint and spine diseases.
1979年，台湾中部发生了一起涉及2000人的大规模中毒事件，这些人因食用了被多氯联苯（PCBs）和多氯二苯并呋喃（PCDFs）污染的食用油。我们研究了暴露个体和社区对照组中疾病的患病率。从1983年的暴露个体登记册开始，我们更新了暴露个体的地址，并确定了一个在年龄、性别和社区方面相匹配的1979年对照组。1993年，对30岁及以上的个体进行了电话访谈。我们从795名暴露受试者和693名对照受试者那里获得了可用信息。在暴露于多氯联苯/多氯二苯并呋喃的男性和女性中，氯痤疮、指甲异常、角化过度、皮肤过敏、甲状腺肿、头痛、牙龈色素沉着和牙齿破损的终生患病率更高。暴露女性报告贫血的频率是对照组的2.3倍。暴露男性报告关节炎和椎间盘突出的频率分别是对照组的4.1倍和2.9倍。在报告的其他疾病患病率方面没有差异。我们得出结论，暴露于高浓度多氯联苯和多氯二苯并呋喃的台湾人报告了更频繁的健康问题，包括皮肤病、甲状腺肿、贫血以及关节和脊柱疾病。
