Guo Y L, Ryan J J, Lau B P, Yu M L, Hsu C C
Environmental and Occupational Health, National Cheng Kung University Medical College, 61 Shiao Tong Road, Tainan, 70428, Taiwan, Republic of China.
Arch Environ Contam Toxicol. 1997 Jul;33(1):104-8. doi: 10.1007/s002449900230.
In 1979, a mass poisoning of more than 2000 people occurred in central Taiwan due to consumption of rice-bran oil contaminated with PCBs and their heat-degraded byproducts. The incident was later referred to as Yucheng (oil disease). Serum samples from 56 women with the 1979 exposure were collected in February 1992 and analyzed for their contaminant content using sample enrichment and isotope dilution mass spectrometry. In most of the samples, levels of PCDFs and PCBs were detectable, and the median values of 2,3,4,7,8-PCDFs and 1,2,3,4,7,8-PCDFs were 1,030 and 2,220 ng/kg serum lipid, respectively. The median level of the total PCBs on a whole weight basis was 8,730 ng/kg. The PCB/PCDF concentrations in Yucheng women 14 years after the toxic exposure were still one to two orders of magnitude higher than controls. Concentrations of PCB levels in 1992 were positively correlated with the 1980-1981 measured PCB levels in these women and both PCBs and PCDFs were negatively correlated with the total duration when these women breast fed their children between 1979 and 1992. It is concluded that serum levels of congener-specific PCBs/PCDFs in exposed women are good indicators of previous exposure and may provide important information for more reliable estimation of dose-response relationship.
1979年，台湾中部发生一起2000多人的大规模中毒事件，原因是食用了被多氯联苯及其热降解副产物污染的米糠油。该事件后来被称为“油症”。1992年2月采集了56名1979年接触污染物的女性的血清样本，并使用样品富集和同位素稀释质谱法分析其污染物含量。在大多数样本中，可检测到多氯二苯并呋喃和多氯联苯的含量，2,3,4,7,8-多氯二苯并呋喃和1,2,3,4,7,8-多氯二苯并呋喃的血清脂质中位数分别为1030和2220纳克/千克。以全重计，多氯联苯的总中位数水平为8730纳克/千克。中毒暴露14年后，“油症”女性体内的多氯联苯/多氯二苯并呋喃浓度仍比对照组高1至2个数量级。1992年的多氯联苯浓度与这些女性1980 - 1981年测得的多氯联苯水平呈正相关，但多氯联苯和多氯二苯并呋喃均与这些女性在1979年至1992年间母乳喂养孩子的总时长呈负相关。研究得出结论，接触污染物女性体内同类多氯联苯/多氯二苯并呋喃的血清水平是既往接触的良好指标，可为更可靠地估计剂量反应关系提供重要信息。
