乳酸脱氢酶缺陷的乳酸乳球菌中乙酸盐的利用：维持氧化还原平衡的一种补救途径。
Acetate utilization in Lactococcus lactis deficient in lactate dehydrogenase: a rescue pathway for maintaining redox balance.
作者信息
Hols P, Ramos A, Hugenholtz J, Delcour J, de Vos W M, Santos H, Kleerebezem M
机构信息
Microbial Ingredients Section, NIZO Food Research and Wageningen Centre for Food Science, 6710 BA Ede, The Netherlands.
出版信息
J Bacteriol. 1999 Sep;181(17):5521-6. doi: 10.1128/JB.181.17.5521-5526.1999.
Abstract
Acetate was shown to improve glucose fermentation in Lactococcus lactis deficient in lactate dehydrogenase. 13C and 1H nuclear magnetic resonance studies using [2-13C]glucose and [2-(13)C]acetate as substrates demonstrated that acetate was exclusively converted to ethanol. This novel pathway provides an alternative route for NAD+ regeneration in the absence of lactate dehydrogenase.
摘要
已表明乙酸盐可改善乳酸脱氢酶缺陷的乳酸乳球菌中的葡萄糖发酵。使用[2-¹³C]葡萄糖和[2-(¹³)C]乙酸盐作为底物的¹³C和¹H核磁共振研究表明，乙酸盐仅转化为乙醇。在缺乏乳酸脱氢酶的情况下，这条新途径为NAD⁺再生提供了一条替代途径。
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