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Acetate utilization in Lactococcus lactis deficient in lactate dehydrogenase: a rescue pathway for maintaining redox balance.乳酸脱氢酶缺陷的乳酸乳球菌中乙酸盐的利用：维持氧化还原平衡的一种补救途径。
J Bacteriol. 1999 Sep;181(17):5521-6. doi: 10.1128/JB.181.17.5521-5526.1999.
2
Metabolic characterization of Lactococcus lactis deficient in lactate dehydrogenase using in vivo 13C-NMR.利用体内¹³C核磁共振技术对乳酸脱氢酶缺陷型乳酸乳球菌进行代谢特征分析。
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3
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4
Is the glycolytic flux in Lactococcus lactis primarily controlled by the redox charge? Kinetics of NAD(+) and NADH pools determined in vivo by 13C NMR.乳酸乳球菌中的糖酵解通量主要受氧化还原电荷控制吗？通过13C NMR在体内测定NAD(+)和NADH池的动力学。
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6
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8
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Eur J Biochem. 2001 Dec;268(24):6379-89. doi: 10.1046/j.0014-2956.2001.02599.x.

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本文引用的文献

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Citrate and Sugar Cofermentation in Leuconostoc oenos, a (sup13)C Nuclear Magnetic Resonance Study.《（sup13)C 核磁共振研究：肠膜明串珠菌中的柠檬酸盐和糖共发酵》
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C Nuclear Magnetic Resonance Studies of Citrate and Glucose Cometabolism by Lactococcus lactis.C 核磁共振研究乳球菌的柠檬酸盐和葡萄糖共代谢。
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Application of C Nuclear Magnetic Resonance To Elucidate the Unexpected Biosynthesis of Erythritol by Leuconostoc oenos.C 核磁共振在阐明肠膜明串珠菌合成赤藓糖醇的意外生物合成中的应用。
Appl Environ Microbiol. 1992 Jul;58(7):2271-9. doi: 10.1128/aem.58.7.2271-2279.1992.
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Citrate Fermentation by Lactococcus and Leuconostoc spp.乳球菌属和肠球菌属的柠檬酸发酵
Appl Environ Microbiol. 1991 Dec;57(12):3535-40. doi: 10.1128/aem.57.12.3535-3540.1991.
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Conversion of Lactococcus lactis from homolactic to homoalanine fermentation through metabolic engineering.通过代谢工程将乳酸乳球菌从同型乳酸发酵转变为同型丙氨酸发酵。
Nat Biotechnol. 1999 Jun;17(6):588-92. doi: 10.1038/9902.
6
Cofactor engineering: a novel approach to metabolic engineering in Lactococcus lactis by controlled expression of NADH oxidase.辅因子工程：通过控制表达NADH氧化酶对乳酸乳球菌进行代谢工程改造的新方法。
J Bacteriol. 1998 Aug;180(15):3804-8. doi: 10.1128/JB.180.15.3804-3808.1998.
7
Cloning of the Lactococcus lactis adhE gene, encoding a multifunctional alcohol dehydrogenase, by complementation of a fermentative mutant of Escherichia coli.通过互补大肠杆菌发酵突变体克隆乳酸乳球菌adhE基因，该基因编码一种多功能乙醇脱氢酶。
J Bacteriol. 1998 Jun;180(12):3049-55. doi: 10.1128/JB.180.12.3049-3055.1998.
8
Control of the shift from homolactic acid to mixed-acid fermentation in Lactococcus lactis: predominant role of the NADH/NAD+ ratio.乳酸乳球菌中从同型乳酸发酵向混合酸发酵转变的调控：NADH/NAD⁺ 比值的主导作用
J Bacteriol. 1997 Sep;179(17):5282-7. doi: 10.1128/jb.179.17.5282-5287.1997.
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Metabolic engineering of sugar catabolism in lactic acid bacteria.乳酸菌中糖分解代谢的代谢工程
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Controlled gene expression systems for Lactococcus lactis with the food-grade inducer nisin.用于乳酸乳球菌的、以食品级诱导剂乳酸链球菌素为基础的可控基因表达系统。
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乳酸脱氢酶缺陷的乳酸乳球菌中乙酸盐的利用：维持氧化还原平衡的一种补救途径。

Acetate utilization in Lactococcus lactis deficient in lactate dehydrogenase: a rescue pathway for maintaining redox balance.

作者信息

Hols P, Ramos A, Hugenholtz J, Delcour J, de Vos W M, Santos H, Kleerebezem M

机构信息

Microbial Ingredients Section, NIZO Food Research and Wageningen Centre for Food Science, 6710 BA Ede, The Netherlands.

出版信息

J Bacteriol. 1999 Sep;181(17):5521-6. doi: 10.1128/JB.181.17.5521-5526.1999.

DOI:10.1128/JB.181.17.5521-5526.1999
PMID:10464231
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC94066/
Abstract

Acetate was shown to improve glucose fermentation in Lactococcus lactis deficient in lactate dehydrogenase. 13C and 1H nuclear magnetic resonance studies using [2-13C]glucose and [2-(13)C]acetate as substrates demonstrated that acetate was exclusively converted to ethanol. This novel pathway provides an alternative route for NAD+ regeneration in the absence of lactate dehydrogenase.

摘要

已表明乙酸盐可改善乳酸脱氢酶缺陷的乳酸乳球菌中的葡萄糖发酵。使用[2-¹³C]葡萄糖和[2-(¹³)C]乙酸盐作为底物的¹³C和¹H核磁共振研究表明，乙酸盐仅转化为乙醇。在缺乏乳酸脱氢酶的情况下，这条新途径为NAD⁺再生提供了一条替代途径。