Khoo U S, Ozcelik H, Cheung A N, Chow L W, Ngan H Y, Done S J, Liang A C, Chan V W, Au G K, Ng W F, Poon C S, Leung Y F, Loong F, Ip P, Chan G S, Andrulis I L, Lu J, Ho F C
Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Pokfulam Road, Hong Kong.
Oncogene. 1999 Aug 12;18(32):4643-6. doi: 10.1038/sj.onc.1202847.
Inherited mutations in the BRCA1 gene confer increased susceptibility to breast and ovarian cancer. Its role in sporadic carcinogenesis is not well defined. Somatic mutations in breast cancers have not been reported and to date there are only three reports of somatic mutations in sporadic ovarian cancers. To investigate the contribution of BRCA1 mutations to sporadic breast and ovarian cancer in the Chinese population, we analysed 62 samples from Chinese women using the protein truncation test. There were 40 cases of breast cancer under age 50 and 22 cases of ovarian cancer, all unselected for family history. There was no age selection for the ovarian cancers. We found two somatic BRCA1 mutations in exon 11, one in a breast cancer and the other in an ovarian cancer, both of which result in truncated proteins. Our results indicate that somatic BRCA1 mutations, like somatic mutations in the BRCA2 gene, though very rare, can be found in both breast and ovarian cancers and support a tumor suppressor function for BRCA1 in sporadic tumors.
